Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0014118 (
endocarditis
)
15,629
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The autopsy specimens of the myocardium and kidneys from 233 patients with infective
endocarditis
(142 and 91 with and without a history of drug abuse, respectively) were studied by conventional microscopy and immunohistochemistry. In the drug abusers (DA), myocytolysis was a dominant form of myocardial damage and in the non-DA that was contraction degeneration. In DA, lower cardiomyocytic
cl-2
expression arouses speculations on the possible role of apoptosis in the pathogenesis of heart failure in this group of patients. Membranous glomerulopathy was a hallmark of renal pathology in DA, contrasting with the predominance of mesangial lesions in non-DA. Increased CIC deposition may be regarded as a major contributing factor.
...
PMID:[Myocardial and renal morphological changes in drug addicts with infective endocarditis]. 1951 56
