Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0014118 (
endocarditis
)
15,629
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Idiopathic hypereosinophilic syndrome was first defined by Chursid et al in 1975; however, following the advances in molecular biology, the World Health Organization has proposed a classification in 2008. Hypereosinophilic syndrome is a heterogeneous group of uncommon disorders characterized by marked peripheral eosinophilia and end-organ manifestation. The authors describe a case of sudden-onset cardiac failure in a young individual who had marked peripheral eosinophilia and detection of
FIP1L1/PDGFRA fusion
gene. A diagnosis of myeloproliferative neoplasm with eosinophilia and eosinophilic
endocarditis
was made. His clinical and laboratory parameters showed a dramatic response to imatinib and prednisone.
...
PMID:Myeloproliferative hypereosinophilic syndrome presenting as cardiac failure and response to imatinib. 2460 76
