Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pseudomonas pickettii is an aerobic, nonfermentative, Gram-negative rod-shaped, bacterium that has been isolated from soil, water, humans, and recently the bovine intestinal tract. It belongs to the rRNA group II of the genus Pseudomonas and has three biovars: Va-1, Va-2, and biovar 3/thomasii. P. pickettii can cause pneumonia, meningitis, endocarditis, and osteomyelitis in humans. It frequently is associated with nosocomial infections that often are linked to contaminated injectable solutions. P. pickettii exhibits remarkable ability to degrade a variety of toxic compounds such as chlorophenols, aromatic hydrocarbons, 2,4-dichlorophenoxyacetic acid, and pentacyclic triterpeniod compounds. The genes that encode for these properties are chromosome- and plasmid-associated. Strains of the organism also have demonstrated resistance to heavy metals, such as cadmium, copper, and zinc. This species can survive in a nutrient-poor environment and use a variety of toxic compounds as carbon and energy sources, making it an ideal candidate for study in the biodegradation of toxic compounds found in wastewater and soils.
 ...
PMID:Pseudomonas pickettii: a common soil and groundwater aerobic bacteria with pathogenic and biodegradation properties. 1102 87

Although the ideal contraceptive has not been found, intrauterine contraceptive devices offer distinct advantages and provide adequate contraception. Unfortunately, they have side-effects, complications and failures. Their use is contraindicated in pregnancy, abnormalities of the uterine cavity, uterine hypoplasia, infection and abnormal uterine bleeding. Patients who have had an ectopic pregnancy, who are prone to endocarditis, who have allergies to copper, or who are taking anticoagulants also should not use IUCDs, Insertion is best performed during menstruation, and the patient should be seen in follow up to assess placement and any side-effects, including cramps, bleeding, vaginal discharge, or discomfort during intercourse. Pregnancy may occur when the IUCD is in place, and prompt diagnosis is mandatory. Depending on the type of IUCD used, replacement time varies from one to three years.
 ...
PMID:Intrauterine contraceptive devices. 2128 76

Endocarditis in a cow. Blackleg in unvaccinated calves. Copper poisoning in pedigree sheep. Malignant oedema in a ram. Salmonellosis in fattening pigs. Fungal pneumonia and airsacculitis in turkeys. Coccidiosis and Marek's disease in gamebirds. These are among matters discussed in the Northern Ireland animal disease surveillance quarterly report for July to September 2015.
 ...
PMID:Northern Ireland disease surveillance report, July to September 2015. 2656 87

The physiological changes that occur during pregnancy can be deleterious to women with a cardiovascular condition. Evidence-based contraceptive counseling and provision is essential in this patient population. Although long-acting reversible contraception (LARCs), which include the intrauterine device (IUD) and the etonogestrel contraceptive implant, have been found to be safe and effective in healthy women, there are inadequate data regarding LARC use in patients with cardiovascular conditions. We conducted a retrospective chart review of women diagnosed with cardiovascular disease who had a copper IUD, levonorgestrel-releasing intrauterine system or contraceptive implant placed at the University of Washington Medical Center from 2007 to 2012. We abstracted and analyzed patient demographic characteristics, medical conditions, indications for LARC placement, and complications. The sample included 470 women with cardiovascular conditions. The mean age was 34.6 years. One hundred twenty-four patients (26.11%) were nulligravid and 169 patients (35.58%) were nulliparous. Four hundred ten chose the levonorgestrel-releasing intrauterine system (87.23%), 33 patients (7.02%) opted for the copper IUD, and 23 patients (4.89%) chose the etonogestrel implant. Eighteen patients (3.83%) had a confirmed IUD expulsion, 2 patients (0.43%) became pregnant, and there were 4 cases of pelvic inflammatory disease (0.85%). There were no cases of perforation. There were no confirmed cases of infective endocarditis associated with LARC insertion. In conclusion, LARC devices appear safe with few complications for women with cardiovascular conditions. Clinicians can be reassured that LARC may be offered as an appropriate option when counseling women with cardiovascular disease on safe contraceptive methods.
 ...
PMID:Efficacy and Safety of Long-Acting Reversible Contraception in Women With Cardiovascular Conditions. 2667 24