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Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rats were immunized with a fusion protein (gal-FnBP) encompassing beta-galactosidase and the domains of fibronectin binding protein from Staphylococcus aureus responsible for binding to fibronectin. Antibodies against gal-FnBP were shown to block the binding of S. aureus to immobilized fibronectin in vitro. Endocarditis in immunized and non-immunized control rats was induced by catheterization via the right carotid artery, resulting in damaged aortic heart valves which became covered by fibrinogen and fibronectin. The catheterized rats were then infected intravenously with 1 x 10(5) cells of S. aureus. The number of bacteria associated with aortic valves was determined 1 1/2 days after the challenge infection and a significant difference in bacterial numbers between immunized and non-immunized groups was then observed (p < 0.05).
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PMID:Immunization with fibronectin binding protein from Staphylococcus aureus protects against experimental endocarditis in rats. 827 22

One hundred one isolates of nutritionally variant streptococci from 97 patients were phenotypically characterized and compared with the type strains of Granulicatella adiacens (formerly Abiotrophia adiacens) (ATCC 49175(T)) Abiotrophia defectiva (ATCC 49176(T)), and Granulicatella elegans (formerly Abiotrophia elegans) (DSM 11693(T)). Of the isolates, 55 and 43 resembled G. adiacens and A. defectiva, respectively, while 3 strains resembled G. elegans. Phenotypic characteristics useful in differentiating between species within the genera Granulicatella and Abiotrophia (G. adiacens, G. elegans, Granulicatella balaenopterae, and A. defectiva) were production of alpha- and beta-galactosidase; production of beta-glucuronidase; hippurate hydrolysis; arginine dihydrolase activity; and acid production from trehalose, sucrose, pullulan, and tagatose. From the reports submitted with the specimens, the clinical diagnosis was endocarditis in 58% of patients and septicemia or bacteremia in 26% of patients.
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PMID:Granulicatella and Abiotrophia species from human clinical specimens. 1157 66

A novel species of the Pasteurellaceae, Avibacterium endocarditidis sp. nov., is proposed based upon characterization of 27 isolates from valvular endocarditis in adult broiler parents. All isolates shared the same PFGE type after digestion of DNA with SmaI and XbaI. In addition, all isolates meet the phenotypic characters for the genus Avibacterium. Separation of the novel species from other species of Avibacterium was possible by means of tests for catalase, symbiotic growth, aerobic growth on agar, acid production from glycerol, xylitol, (+)-L-arabinose, (-)-D-mannitol, (-)-D-sorbitol, (-)-L-fucose, (+)-D-galactose, maltose, trehalose, raffinose and dextrin in addition to reactions with ONPG (beta-galactosidase) and PNPG (alpha-glucosidase). The closest relationship was observed with Avibacterium gallinarum which, however, can be separated from Avibacterium endocarditidis in acid production from (-)-D-mannitol, (-)-D-sorbitol and (-)-L-fucose. The highest 16S rRNA gene sequence similarity (98.4 %) was found to strain Modesto, belonging to serogroup C of Avibacterium paragallinarum. recN gene DNA sequence similarities corrected by the formula of Zeigler (2003) (Int J Syst Evol Microbiol 53, 1893-1900) documented 85 % or less DNA sequence similarity between the type strain of Avibacterium endocarditidis and species of Avibacterium, confirming the separate species status of this taxon according to the multilocus sequence analysis method of Kuhnert & Korczak (2006) (Microbiology 152, 2537-2548). The type strain of Avibacterium endocarditidis sp. nov., strain 20186H4H1(T) (=CCUG 52860(T) =DSM 18224(T)), was isolated from valvular endocarditis of a chicken in Denmark in 2004.
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PMID:Avibacterium endocarditidis sp. nov., isolated from valvular endocarditis in chickens. 1768 46

The initial isolation of Helcococcus ovis from a valvular thrombus prompted us to investigate the prevalence of this bacterium in bovine valvular endocarditis. Specimens from 55 affected hearts were examined by culture using Columbia blood agar and cross streaking the inoculated plate with a Staphylococcus aureus strain. As confirmed by 16S rRNA gene sequencing, H. ovis was isolated with an unexpectedly high frequency of 33%, predominantly as heavy growth and pure culture. The majority of H. ovis isolates showed distinct satellitism around S. aureus and pyridoxal dependency, resembling "nutritionally variant streptococci" (now assigned to the genera Abiotrophia and Granulicatella). Using the API rapid ID 32 Strep, API ZYM, and Rosco Diatabs systems, incongruent results were obtained for alkaline phosphatase, beta-galactosidase, beta-glucuronidase, and leucine aminopeptidase activities. Based on the satellitism/pyridoxal dependency; hemolysis on blood agar; the API rapid ID 32 Strep results for arginine dihydrolase, alpha-galactosidase, beta-galactosidase, beta-glucuronidase, and pyroglutamic acid arylamidase activities; hippurate hydrolysis; and acidification of sucrose, a scheme for the identification of H. ovis and its differentiation from other members of the Helcococcus genus and the pyridoxal-dependent species Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans is proposed. By establishing specific fluorescence in situ hybridization, large H. ovis aggregates were specifically detected within the fibrinous exudate of the valvular thrombi. Our results demonstrate for the first time that H. ovis represents an emerging pathogen in bovine valvular endocarditis that is frequently isolated if appropriate culture conditions are used.
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PMID:Helcococcus ovis, an emerging pathogen in bovine valvular endocarditis. 1871 28