Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We evaluated late clinical results of 134 hospital survivors, of whom 152 patients underwent isolated mitral valve replacement with bioprosthesis from September, 1976 to July, 1989 for acquired valvular heart diseases. One hundred fifty-two bioprosthesis consisted of Hancock porcine aortic, 44, Carpentier-Edwards porcine aortic, 28 Ionescu-Shiley pericardial 46 and Carpentier-Edwards pericardial 34. The cumulative follow-up period was 1151.0 patient.year (pt.yr). The actuarial survival rate with Kaplan-Meier method was 82.4%, 79.9%, 76.0% at 5, 7 and 10 years respectively. The actuarial event free rate of primary tissue failure was 96.7%, 82.8% and 56.7% at 5, 7 and 10 years respectively. The linealized rate of bioprosthetic valve endocarditis was 0.3%/Pt.yr. Although 104 patients (77.6%) of 134 received postoperative anticoagulant therapy with Warfarin sodium about for one year. Thromboembolic complications occurred at rate of 1.3%/Pt.yr. The bioprosthesis in the mitral position is now used only in the selected patients because of the limited long term durability and necessity of permanent anticoagulant therapy.
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PMID:[Long-term results of isolated mitral valve replacement using bioprosthesis]. 833 48

We recently performed a laparoscopic cholecystectomy on three patients receiving preoperative oral anticoagulant therapy. The patients requiring anticoagulants for pre-existing cardiac conditions have the following risks at surgery: thromboembolism, hemorrhage, endocarditis, and cardiopulmonary dysfunction. In patients receiving anticoagulant therapy, one must thus maintain a balanced international normalized ratio of the prothrombin time to prevent thromboembolism or hemorrhage. Warfarin sodium was discontinued preoperatively in all patients. Heparin sodium was individualized according to each patient's risk of thromboembolism. As a result, these patients all underwent a laparoscopic cholecystectomy without complications. Attention was paid to achieve hemostasis in the operative field and the trocar inserted sites during the procedure. The administration of warfarin sodium was resumed on the first postoperative day in all patients. Restarting warfarin sodium early also helps to simplify postoperative management. A broad spectrum of antibiotic therapy was also used to reduce the risk of endocarditis. Each patient's cardiopulmonary function was carefully monitored. The minimal invasion experienced during a laparoscopic cholecystectomy may thus facilitate the management of gallstones in patients receiving systemic anticoagulation treatment based on the findings of this limited series.
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PMID:Laparoscopic cholecystectomy in patients undergoing anticoagulant therapy. 954 16