Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Erysipelothrix Rhusiopathiae is a Gram-positive bacillus that is ubiquitous in nature. The bacterium is a zoonotic pathogen known to infect wild and domestic animals. Human infections, however, are uncommon and typically present with localised or generalised cutaneous lesions. Systemic infection in the form of bacteraemia with seeding to various organs is the least common form of the disease. Infections in humans tend to be associated with occupational exposure and close contact with animals. Clinical data of a 61-year-old male patient with Gram-positive bacilli bacteraemia and E. Rh usiopathiae-induced endocarditis are presented here. The patient presented with refractory congestive heart failure secondary to severe acute aortic regurgitation mandating surgical valve replacement. The described case has special clinical merit given the lack of fever and leukocytosis, absence of erysipeloid cutaneous manifestations and refractoriness to medical management. E. Rhusiopathiae should be considered in the differential diagnosis for Gram-positive bacilli bacteraemia and endocarditis. In the proper clinical setting, occupational exposure and animal contacts are helpful clues to raise suspicion for this bacillus. The high mortality associated with the pathogen should urge for early identification and initiation of antimicrobial treatment.
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PMID:Native valve endocarditis caused by E rysipelothrix Rh usiopathiae: presenting with refractory heart failure and requiring surgical valve replacement-report on a rare zoonosis. 3186 13

Erysipelothrix rhusiopathiae is an omnipresent commensal in the environment, studied for over a century. It is a zoonotic pathogen known to cause infections in animals and humans. Cases of Erysipelothrix rhusiopathiae in humans have been classified into three distinct entities: localized skin infections, diffuse skin infections, and systemic organ involvement. This particular pathogen is an uncommon cause of endocarditis, with an affinity for the aortic valve. We present a case of Erysipelothrix rhusiopathiae in a patient with involvement of the tricuspid valve.
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PMID:An Unusual Case of Tricuspid Valve Infective Endocarditis Caused by Erysipelothrix Rhusiopathiae. 3249 82

Erysipelothrix rhusiopathiae, is an important animal pathogen, but rarely reported in humans. To date, only few cases of infective E.rhusiopathiae endocarditis of the aortic valve have been described. We introduce the first reported case of native unicuspid aortic valve severe damage complicated with acquired ventricular septal defect caused by E.rhusiopathiae endocarditis. This case may provide a better understanding of the disease process, transmission and underlines the need to include this pathogen in differential diagnosis of infective endocarditis.
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PMID:Erysipelothrix rhusiopathiae endocarditis in a patient with severe unicuspid aortic valve damage complicated with acquired ventricular septal defect. 3292 Jan 67

Erysipelothrix rhusiopathiae is a zoonotic gram positive coccobacillus. It is rarely found in humans as an occupational pathogen that mainly infects animal handlers. There are three forms of human infection: localized erysipeloid, diffuse cutaneous form and lastly, bacteremia that could progress to infective endocarditis. We present a case of a 59-year-old male who was found to have E. rhusiopathiae bacteremia that was diagnosed as aortic valve endocarditis with severe aortic regurgitation. The patient was treated with ampicillin-sulbactam then transitioned to six weeks of intravenous ampicillin. This report summarizes a rare organism that causes a serious human infection and discusses its epidemiology, clinical presentation, diagnosis and treatment options.
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PMID:Erysipelothrix rhusiopathiae endocarditis. 3299 74


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