Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease may manifest clinically as septic fever (40 degrees C), acute pseudogout attack of knee, wrist and shoulders, or as a variety of patterns of chronic inflammatory or degenerative joint disease. The association of pseudogout with fever is less widely recognised and may lead to over-investigation, delay in appropriate treatment and disproportionate costs. We report on a 67-year-old woman with a history of recurrent episodes of fever and polyarthritis every 2 months for the last 3 years. Because of this she was hospitalised several times, finally with suspected culture-negative endocarditis, and was treated for 6 weeks with gentamicin, rifampicin and vancomycin. During this therapy the patient again developed septic fever and acute arthritis of the right wrist. Radiographs of the wrist, knee and symphysis pubis revealed prominent chondrocalcinosis and destructive arthropathy.
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PMID:[Fever of unknown origin as a sign of calcium pyrophosphate deposition disease]. 1080 2

The polyarthritis is a relatively frequent situation which can translate a whole set of diverse and varied etiologies. A careful history and physica examination are key to accurate diagnosis of polyarthritis: the context, the topography of the articular involvement, the existence of general signs and extra-articular signs are crucial. It is advisable first of all to eliminate the infectious disease especially in case of fever (endocarditis). It is also necessary to look for a microcrystalline arthritis (gout, chondrocalcinosis) which the treatment justifies specific measures. Once these spread diagnoses, we can envisage an inflammatory rheumatism chronic and first of all, a rheumatoid arthritis (symmetric bilateral polyarthritis affecting hands and respecting distal interphalangeal joints). The rheumatoid arthritis is an urgency diagnosis: it requires an early, specialized, individualized and multidisciplinary care. The rapid institution of a disease-modifying antirheumatic drug can allow obtain a remission, mproves clinical outcomes and reduces the accrual of joint damage and disability.
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PMID:[The main directions in case of polyarthritis]. 2322 98