Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The author has analysed the renal alterations in 8 patients, each of whom died of renal failure. Extracapillary crescents had developed in more than 50% of the glomeruli in all of them. Renal symptoms followed those of endocarditis after two weeks. Proteinuria, haematuria and impairment of renal functional parameters featured the clinical course of the disease. From the haemoculture, bacteria (in 6 cases) and fungus (in one case) were isolated. Haemoculture was negative in one case. The obtained serum complement values, intraglomerular immunoglobulin and/or complement depositions, electron-dense deposits along the glomerular basement membrane and within the mesangium all proved the presence of an immunocomplex mechanism. The rapid course leading to renal failure can be explained by the abundant crescent formation.
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PMID:Crescentic involved glomerulonephritis in infective endocarditis. 238 6

Renal involvement (RI)--defined as proteinuria greater than 150 mg per 24 h with haematuria or impaired glomerular filtration rate--was studied in 80 patients with infective endocarditis (IE). Proteinuria was measured quantitatively and further differentiated by the SDS-polyacrylamide-gel electrophoresis. RI was found in 40 patients (50%) with proteinuria from 150 to 8000 mg per 24 h. SDS-PAGE revealed a tubular protein pattern in 17 patients, a glomerular pattern in 6 and a glomerulo-tubular pattern in 17. Mortality rate was significantly higher in patients with RI (40%) than in those without (7.5%), and was not related to the type of infected valve, infective organisms, method of treatment (surgical or medical) or embolic events. Following successful treatment of IE, 18 out of 23 patients showed complete normalization of renal function. Renal involvement in patients with IE may be of prognostic significance--indicating an impaired prognosis.
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PMID:Is renal involvement a prognostic parameter in patients with infective endocarditis? 651 93