Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vegetative endocarditis on the prolapsing mitral valve can be diagnosed with an echocardiogram and the response to therapy can be followed with this technique. A dense mass of fuzzy echoes was noted on the prolapsing posterior leaflet of an echocardiogram from a patient with endocarditis. Three months after the initiation of antibiotic therapy, the mass of echoes had disappeared and was replaced by a dense linear echo, suggesting fibrosis of the part of the mitral valve that had been infected previously. Persistence of the echocardiographic evidence of endocarditis, despite negative blood cultures, may indicate persistence of the risk of peripheral embolization.
 ...
PMID:Vegetative bacterial endocarditis on the prolapsing mitral valve. Echocardiographic evaluation. 86 51

Verrucous endocarditis in the newborn is not only a rare but also a problematic disease as concerns its etiology and pathogenesis. In the older literature septic infections of mother and child were said to be the causative factors. Recent experiences with the pathophysiology and pathomorphology of shock have also shown new aspects of the origin of this kind of endocarditis. Two cases from our own experience are compared with 7 cases from the literature. In the maternal history of gestation there was no infectious disease which could explain the endocarditis of the newborn. A short time after delivery the children showed a respiratory distress syndrome and died between 1.5 hours and 3 days after birth. At autopsy verrucous vegetations up to 8 X 5 X 4 mm in diameter were found on the tricuspid valve in 8 cases, once on the mitral valve and twice on both mitral and tricuspid valve. Malformations of the hearts were not noted. Histologically the fresh vegetations consist of clotted platelets and a fibrin network. At the base of the verruca the valvular leaflets show an edema, occasional fibroblastic changes and tiny lympho-histiocytic infiltrates in the subendothelial layer. Extracardial findings are hyaline membranes of the lungs and microthrombi in small vessels of lung, heart, liver and kidney due to shock and consumption-coagulopathy. According to Mittermayer et al. (1971a, b) who studied endocarditis verrucosa simplex in adults and animal-experiments endocarditis verrucosa simplex of the newborn is probably caused by intrauterine or perinatal shock.
 ...
PMID:[Pathogenesis of endocarditis verrucosa simplex in the newborn (author's transl)]. 92 7

This paper describes the case histories of two Thoroughbred horses, a 2-year-old colt in training and a 7-year-old broodmare, that were presented with histories of weight loss, exercise intolerance, intermittent fever, limb oedema and anaemia. Vegetative endocarditis of the mitral and tricuspid valves was diagnosed in the colt by means of echocardiography. Pseudomonas sp. endocarditis of the mitral valve was diagnosed in the mare using echocardiography and bacterial culture. The colt had secondary congestive heart failure and was euthanased on humane grounds. Pseudomonas cepacia was isolated from the vegetative lesions following the post mortem examination. The mare was sent home and treated with gentamicin at a dosage of 3.3 mg/kg intra-muscularly twice daily for ten days. Her condition improved and she returned to stud.
 ...
PMID:Pseudomonas spp. associated vegetative endocarditis in two horses. 859 90

Verrucous endocarditis of the aortic valves was diagnosed postmortem in a Persian cat that died after showing clinical signs of dyspnoea, hypothermia and anorexia. Bacterial colonies were evident on Giemsa-stained sections of the valves and Escherichia coli was isolated from the endocarditis lesions.
 ...
PMID:Verrucous endocarditis due to Escherichia coli in a Persian cat. 978 48