Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The heart of a 44 years old man who died of a severe calcifying endocarditis of the aortic valves and the aortic root demonstrated a rare anomaly of the coronary arteries. The ostium and the stem of the left coronary artery were missing. In the left aortic sinus there was a small dimple covered by calcified tissue. Using histological serial sections a small vessel was detected that was completely obliterated by organized thrombotic tissue running between the small dimple in the aortic sinus and the main branches of the left coronary artery. This vessel was supposed to be the remaining stem of the left coronary artery. The regular branches of the left coronary artery were supplied by an anastomosis between the proximal part of the right coronary artery and the descending branch of the left coronary artery running within the upper interventricular septum. It has been suggested that this rare anomaly was caused by a gradual obliteration of the ostium and the stem of the left coronary artery during the course of the calcifying rheumatic endocarditis of the aortic valves.
 ...
PMID:[Pathogenesis of acquired coronary anomalies. Case report]. 111 61

The clinical findings and the necropsy report of a 14-year-old girl suffering from Takayasu's arteriopathy have been presented. In addition to the typical arterial changes, thickening and puckering of the aortic valve and a patch of thickening in the left atrial endocardium were shown at necropsy. The histology of this lesion was found to be identical with the arterial intimal changes. It has been postulated that Takayasu's arteriopathy may rarely extend to the valvular and mural endocardium of the heart, producing cardiac murmurs. Similar cases with cardiac murmurs reported earlier and attributed to associated rheumatic endocarditis were probably due to the same pathological process extending to the endocarditis.
 ...
PMID:Endocardial lesion in a case of Takayasu's arteriopathy. 415 54