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Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hemostatic physiology involves a complex interlinking of blood and endothelial factors. Its pharmacological manipulation invariably impacts at multiple molecular sites. Herein is reported an unusual case of coexistent warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for thromboembolic phenomena associated with marantic endocarditis and bronchial adenocarcinoma. Thrombophilia in the face of endocarditis should be treated with a suspicion of underlying cancer.
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PMID:Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis. 1704 80

Marantic endocarditis (ME) is defined by noninfectious valvular vegetations. The most common disorders associated with ME are malignancy with or without hypercoagulable state, intercardiac instrumentation, residual vegetations from previously treated infective endocarditis (IE), renal insufficiency, and burns. Another important cause of ME is systemic lupus erythematosus when accompanied by vegetations, that is, Libman-Sacks endocarditis. ME should be differentiated from IE because they may present with similar clinical features. Both ME and IE may present with fever and a heart murmur with or without embolic phenomenon. Leukocytosis and elevated erythrocyte sedimentation rate suggest the diagnosis of IE. The hallmark of IE is a cardiac vegetation and continuous high-grade bacteremia. After exclusion of the causes of culture negative endocarditis, the absence of bacteremia clearly differentiates ME from IE. We present a case of ME mimicking acute bacterial endocarditis (ABE). The differential diagnostic features of ME versus IE are discussed. To the best of our knowledge, this is the first reported case of quadrivalvular ME with massive vegetations on all cardiac valves, as well as the aorta, atria, and pulmonary artery.
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PMID:Quadrivalvular marantic endocarditis (ME) mimicking acute bacterial endocarditis (ABE). 1736 97

Non-bacterial thrombotic endocarditis (NBTE) is a rare disorder characterized by sterile, thrombotic vegetations of the heart valves. Clinically, NBTE occurs in the setting of various malignancies and autoimmune phenomena, notably antiphospholipid syndrome. Echocardiographically, NBTE can resemble infective endocarditis, acute rheumatic fever and chronic rheumatic disease. The thrombotic lesions of NBTE carry significant embolic potential, and do not respond uniformly to anticoagulation. Valve deformity, resulting in severe stenotic and/or regurgitant lesions, while rare, may necessitate surgical intervention. Herein is described the case of a young female with a history of a spontaneous abortion who presented with an ischemic neurologic event. Transesophageal echocardiography revealed multiple mitral valve vegetations. Repeated negative blood cultures along with persistently elevated anticardiolipin antibody titers suggested a diagnosis of non-bacterial thrombotic endocarditis secondary to antiphospholipid syndrome. The pathology, echocardiographic findings, clinical features and treatment of this uncommon valvulopathy are discussed.
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PMID:The valvulopathy of non-bacterial thrombotic endocarditis. 1945 90

Nonbacterial thrombotic endocarditis is a condition characterized by noninfectious valvular vegetations and is associated with numerous conditions, including the antiphospholipid syndrome. Although vegetations most frequently affect the left-sided valves, isolated involvement of the right-sided valves rarely occurs. Ideal management of the lesions, from both medical and surgical perspectives, is not well defined. The authors report the case of a patient who presented with clinically symptomatic isolated tricuspid valve and right atrial nonbacterial thrombotic endocarditis due to primary antiphospholipid syndrome, who was subsequently managed with diuretics and anticoagulation and has remained clinically stable.
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PMID:Extensive nonbacterial thrombotic endocarditis isolated to the tricuspid valve in primary antiphospholipid syndrome. 1976 75

Non-bacterial thrombotic endocarditis or marantic endocarditis is an uncommon and frequently terminal condition. We report non-bacterial thrombotic endocarditis presenting as a psychotic illness. The underlying cause was found to be adenocarcinoma of the lung. The patient was nursed on a specialist joint medical/psychiatric unit. Many medical illnesses can present with psychosis in older people: this is the first case report of this presentation in non-bacterial thrombotic endocarditis.
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PMID:Psychosis due to non-bacterial thrombotic endocarditis. 2005 99

The term nonbacterial thrombotic endocarditis (NBTE), or marantic endocarditis, refers to a spectrum of lesions ranging from microscopic aggregates of platelets to large vegetations on previously undamaged heart valves (most often aortic and mitral) in the absence of a bloodstream bacterial infection. NBTE is a rare condition often associated with hypercoagulable states or advanced malignancy such as adenocarcinomas. In this article, the pathogenesis, incidence, clinical manifestations, diagnosis, and management of NBTE in cancer patients are reviewed.
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PMID:Nonbacterial thrombotic endocarditis (marantic endocarditis) in cancer patients. 2039 72

Marantic endocarditis, otherwise known as nonbacterial thrombotic endocarditis (NBTE), is a well-documented phenomenon due to hypercoagulability from an underlying cause. It has been associated with a variety of inflammatory states including malignancy. Surprisingly, although hypercoagulability is often seen in patients with pancreatic cancer, marantic endocarditis has rarely been reported antemortem in this population. We report three cases of marantic endocarditis in patients with advanced pancreatic cancer. In two instances, the patients' neurological symptoms preceded the diagnosis of advanced pancreatic cancer. Health care professionals should be alert to the possibility of marantic endocarditis in any patient with cancer, especially pancreatic cancer, who presents with symptoms of neurological dysfunction or an arterial thrombotic event. Prompt diagnosis and treatment with heparin, unfractionated or low molecular weight, may prevent catastrophic CNS events and decrease morbidity in patients with pancreatic cancer and other malignancies.
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PMID:Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series. 2065 68

We report on two patients hospitalized in intensive care unit for ischemic strokes presenting the feature of marantic endocarditis complicating lung's adenocarcinoma. These two cases turned out to be very interesting because of the occurrence of ischemic strokes even though the patients were receiving the recommended treatment, namely anticoagulation with heparin, in well-adjusted doses. The management of nonbacterial thrombotic endocarditis remains a challenge and its mortality is still high.
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PMID:[Ischemic strokes as a presenting feature of marantic endocarditis despite heparin treatment]. 2072 81

Nonbacterial thrombotic endocarditis (NBTE) is a disease characterized by deposition of thrombi and fibrin on normal or degenerated cardiac valves in the absence of microorganisms. This condition is more commonly seen in chronic inflammatory states, and is associated with higher incidence of thromboembolic events than infective endocarditis. We report the case of a 63-year old male patient with adenocarcinoma of unknown primary site and systemic embolism.
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PMID:Marantic endocarditis and adenocarcinoma of unknown primary site. 2155 51

Non-bacterial thrombotic endocarditis is caused by a hypercoagulable state that is sometimes related to malignancy and this type of endocarditis associated with benign tumors has not yet been reported. In this study we report the first case of non-bacterial thrombotic endocarditis caused by adenomyosis, which is a benign gynecological condition.
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PMID:Non-bacterial thrombotic endocarditis with systemic embolic events caused by adenomyosis. 2182 68


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