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Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Terminal endocarditis develope in cancer patients almost latently. There is no difference between the so-called "tumor-endocarditis" and other verrucous endocarditis associated with terminal tuberculosis, sepsis or rheumatism. It is more frequent in cases with large or ulcerated primary tumours and multiple metastases than in cases with early cancer. It also develope more frequently in well differentiated cancer (squamous and adenocarcinoma) than in indifferentiated forms of cancer. Terminal endocarditis is often seen in patients with cancer of the gallbladder, pancreas, liver, stomach, rectum, and ovary. In carcinoma of the liver, pancreas and biliary tract the trend to embolism is more reduced through icterus than the trend to terminal endocarditis.
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PMID:[Endocarditis in cancer necropsies (author's transl)]. 47 52

A consecutive series of 1288 mitral valves surgically excised from 1981 through 1989 were studied macroscopically and histologically. The explanted valves were affected by: chronic rheumatic disease (1179, 91.5%), floppy mitral valve (84, 6.5%), bacterial endocarditis (19, 1.5%), and post-ischemic mitral incompetence (6, 0.5%). Among 1179 post-rheumatic cases, mixed mitral stenosis and incompetence was the most frequent malfunction (747, 58%). Isolated mitral incompetence was diagnosed in 72 (6.11%) cases only, and isolated stenosis in 360 cases. In 52 valves, excised because of chronic rheumatic disease, the histology showed unexpected signs of acute rheumatism of the leaflets and the papillary muscles. In these patients clinical symptoms and blood tests were negative for rheumatic disease. Mitral incompetence, possibly due to papillary muscle dysfunction, was the prevalent lesion (61.5%). A total of 181 patients (14.05%) with pure mitral incompetence underwent surgery. In 84 patients (46.4%), the floppy mitral valve was the most frequent cause of valve dysfunction, 72 (39.8%) had rheumatic disease, 19 (10.5%) infective endocarditis, and 6 (3.4%) ischemic heart disease. In the group with floppy mitral valve, males were more prevalent than females (51:33). The mean age of the 4 patients with Marfan's syndrome and non-Marfan patients was noticeably different (17 vs 49 yr). Moreover leaflet deformation, tendinous cord elongation and annulus dilatation were the most common causes of valve incompetence. Floppy mitral valve and infective endocarditis were the cause of cordal rupture in 43.5% of the cases. This was a severe complication which always required emergency surgery.
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PMID:Surgical pathology of the mitral valve: gross and histological study of 1288 surgically excised valves. 142 93

Nineteen patients with infective endocarditis underwent surgery. Congenital heart disease was found in 6 patients, valve disease in 13. Seven patients had history of rheumatism. Congestive heart failure was noted in 17 patients, arterial embolism in 3, and pulmonary infarction in 1. Blood culture was positive in 36.8%, while vegetations were detected echocardiographically in 58.8% of the patients. Selective surgery was performed in 17 patients and emergency operation in the rest two. There was no operative death. Follow-up for 3-109 months after operation showed no evidence of recurrent endocarditis. We suggest that early surgical treatment is mandatory for intractable infective endocarditis if excellent result is expected.
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PMID:[Surgical treatment of infective endocarditis]. 181 20

The adrenals of 65 patients who had died of rheumatism, endocarditis septica lenta, simple chronic bronchitis, atherosclerotic cardiosclerosis and acute trauma were studied histologically, histochemically, morphometrically and using impregnation methods. Processes in the stroma and endocrine tissue were divided into two groups. The first group included changes relating to the manifestation of general adaptation syndrome. The second one deals with changes reflecting the features of the given disease pathogenesis: degenerative and inflammatory processes typical for certain conditions, various states of different adrenal zones.
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PMID:[Morphofunctional characteristics of the adrenals in patients with cardiovascular pathology]. 185 79

From July 1981 to October 1988, 1597 native valves, 926 (58%) mitral and 671 (42%) aortic, were excised. The gross and histological features of all valves were studied using routine histochemical, immunohistochemical and electron microscopy techniques. As far as mitral valve is concerned the lesions were: stenosis 263 (28.6%), stenosis + incompetence 537 (57.8%) and incompetence 126 (13.6%). Our study was limited to the valves of patients undergoing mitral valve replacement because of pure incompetence. The pathological alterations of the valves were: floppy mitral valve (FMV) 59 (46.8%), rheumatic disease (RD) 50 (39.6%), infective endocarditis (IE) 13 (10.3%), papillary muscles ischemic disease (PMID) 4 (3.1%). In the FMV group the associated lesions were: aortic valve incompetence due to floppy aortic valve and noninflammatory aortic root disease (9-15.2%), tricuspid valve incompetence (4-7.8%) and atrial septal defect (7-13.7%). The commonest complication in this group was rupture of chordae tendineae requiring urgent surgery. In the RD group there was a high incidence of active rheumatism, valvulitis and papillary muscles myocarditis (37-74%) despite the laboratory data were within normal ranges. In the IE group there was an associated aortic endocarditis in 7 patients (53.8%). The FMV was the commonest cause of pure incompetence in patients who had mitral valve replacement. Rheumatic pure mitral incompetence was always associated in our experience to signs of active rheumatic disease.
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PMID:[Etiology and incidence of pure mitral insufficiency: a morphological study of 926 native valves]. 224 33

We conducted an echocardiographic study to determine the incidence and spectrum of morphologic and functional cardiac abnormalities in systemic lupus erythematosus (SLE) and to relate these findings to the disease activity and duration, and the presence of antiphospholipid (APL) antibodies. Thirty consecutive patients with LES (5 male and 25 female, mean age 37 +/- 11 years) were studied with a clinical cardiovascular examination and M-mode, 2-D Doppler echocardiogram. All patients fulfilled the American Rheumatism Association criteria for diagnosis of SLE. Disease activity was scored using the "Lupus Activity Criteria Count". The duration of the disease was less than 1 year in 5 patients (16.7%), between 1 and 5 years in 7 (23.3%), and superior to 5 years in 18 (60%). No patient had a history of rheumatic fever or infective endocarditis. All patients had received steroid therapy. In 26.7% of patients the disease was active, and in 33.3% APL antibodies were present. Patients were matched by number, age and sex with the control group. In 73.3% of the patients the echocardiogram resulted abnormal; valvular disease occurred in 30% and the echocardiographic features were of diffuse thickening, with 4 mitral and 2 aortic regurgitations. No valvular dysfunctions were significant, nor was Libman-Sacks endocarditis present. Pericardial disease, effusion or thickening was detected in 33.3% of the echocardiograms. Furthermore, there was one patient with left ventricular mild hypertrophy; 2 with a mild enlargement of the left ventricle with no segmental abnormalities of wall motion and no systolic disfunction; 8 patients (26.7%) were normal. Compared with the control group, patients with SLE had an increased prevalence of echocardiographic abnormalities, especially pericardial (p < 0.001) and valvular (p < 0.01). No association was found between activity, duration of the disease and prevalence of cardiac abnormalities. On the contrary, an association between the presence of APL antibodies and cardiac abnormalities at the echocardiographic examination was evident (p < 0.05).
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PMID:[Cardiac anomalies in systemic lupus erythematosus: their prevalence and relation to duration, disease activity and the presence of antiphospholipid antibodies]. 816 2

A case of systemic lupus erythematosus (SLE) associated with fever, heart failure, and left ventricular (LV) aneurysm is reported. A diagnosis of SLE was suspected owing to the presence of active lymphocytic myocarditis and fibrinous endocarditis at LV endomyocardial biopsy and was confirmed by identification of 4 of the 11 criteria proposed by the American Rheumatism Association for the definition of SLE. A 2-month period of steroid therapy was followed by a remarkable recovery of LV function and progression of endomyocarditis to a healed phase at control LV biopsy. The LV aneurysm disappeared, likely because thrombosis occurred as a result of the hypercoagulable state accompanying the presence of anticardiolipin antibodies. This is the first reported case of LV aneurysm induced by SLE and is a rare clinicohistologic documentation of the effectiveness of steroid treatment on lupus endomyocarditis.
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PMID:Acute myocarditis and left ventricular aneurysm as presentations of systemic lupus erythematosus. 854 1

1. Repeated injections into rabbits of non-hemolytic streptococci isolated from human cases of infectious endocarditis or rheumatic fever will produce an acute arthritis in the rabbit similar in most respects to the arthritis of acute rheumatism. 2. Microscopical sections of the joints show a gradual transition from an acute exudative inflammation to advanced organization. 3. Endocarditis and pericarditis occur in a small percentage of cases, and focal lesions in the myocardium consisting of necrosis and the infiltration of cells are frequent. These focal lesions differ considerably from Aschoff's submiliary nodules. 4. Lesions in the kidneys and liver occur but are not characteristic. 5. By means of the vital stain it has been shown that the large endothelioid cells which play a prominent part in the joint and myocardial lesions belong to the group of so called macrophages or wandering cells and probably develop from the vascular endothelium.
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PMID:A STUDY OF EXPERIMENTAL NON-HEMOLYTIC STREPTOCOCCUS LESIONS IN VITALLY STAINED RABBITS. 1986 70

The polyarthritis is a relatively frequent situation which can translate a whole set of diverse and varied etiologies. A careful history and physica examination are key to accurate diagnosis of polyarthritis: the context, the topography of the articular involvement, the existence of general signs and extra-articular signs are crucial. It is advisable first of all to eliminate the infectious disease especially in case of fever (endocarditis). It is also necessary to look for a microcrystalline arthritis (gout, chondrocalcinosis) which the treatment justifies specific measures. Once these spread diagnoses, we can envisage an inflammatory rheumatism chronic and first of all, a rheumatoid arthritis (symmetric bilateral polyarthritis affecting hands and respecting distal interphalangeal joints). The rheumatoid arthritis is an urgency diagnosis: it requires an early, specialized, individualized and multidisciplinary care. The rapid institution of a disease-modifying antirheumatic drug can allow obtain a remission, mproves clinical outcomes and reduces the accrual of joint damage and disability.
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PMID:[The main directions in case of polyarthritis]. 2322 98