Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Laennec's lung disease lasted for at least 20 years. Its stigmata included chronic cough, sputum production and intermittent wheeze. 2. Laennec had long term stigmata commonly associated with chronic bronchiectasis, sinusitis, physical frailty, and short stature (5ft 2in). 3. Chronic diarrhoea of at least 20 years duration is not strongly associated with tuberculosis. 4. During Laennec's last illness his physicians equivocated as to whether he had respiratory disease at all. Bronchial breathing at the apex, if indeed present, could have been caused by compensatory emphysema secondary to middle lobe bronchiectasis rather than to active tuberculosis. 5. Laennec did not have haemoptysis in his final illness. 6. Laennec's last illness, a wasting illness characterised by intermittent fevers, cardiac murmur, and persistent tachycardia followed a dental manipulation. The painful "abdominal abscess" noted by Laennec's colleagues may actually have been splenomegaly. These features suggest endocarditis. The cardiac murmurs associated with pulmonary hypertension secondary to bronchiectasis are not usually audible at a remote distance from the patient. Endocarditis was a disease largely unknown to physicians of the early 19th century before Osler clarified its pathology in the 1880s.
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PMID:Rene Laennec: his brilliant life and tragic early death. 266 72

The letters of referral to the hospital with respect to 70 dental patients with medical problems relevant to dental treatment were studied for information about the medical history. The relevant medical history had been documented in fewer than 40% of the referrals. Referrals from medical practitioners more frequently contained relevant histories (57%) than did those from dental practitioners (34%). Some important problems, such as the tendency to bleed and the predisposition to infective endocarditis, were documented in most instances but other problems, such as a history of corticosteroid treatment or of respiratory disease, were often omitted. Dental practitioners should appreciate that their documentation of medical problems is not superfluous since it helps by providing another line of defense against error.
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PMID:Medical information from referral letters. 348 Apr 82

Fifty-eight cases of bacteremia due to Moraxella catarrhalis, including seven that occurred in patients treated at our facilities, are analyzed. The host's medical history plays a major role in the presentation and outcome of M. catarrhalis bacteremia. Bacteremia is typically accompanied by pneumonia in adults with underlying respiratory disease. Many neutropenic patients do not manifest a focus of infection; in contrast, the source identified in healthy, immunocompetent patients is usually the upper airway or the ears. In the recent literature, it has been reported that a rash is typically absent in adults with bacteremic pneumonia and in immunocompetent hosts and that only some neutropenic patients have a rash. The prognosis is grave for patients with endocarditis and for patients with immunoglobulin deficiency or neutropenia not related to a hematologic malignancy. In addition, mortality is substantial among bacteremic patients with respiratory conditions or other chronic debilities, especially when respiratory copathogens are present. The prognosis is good for febrile neutropenic patients with underlying leukemia or lymphoma when the neutropenia resolves. When healthy, immunocompetent individuals are affected with M. catarrhalis bacteremia, their presentations range from self-limited febrile illness to life-threatening disease.
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PMID:Spectrum and significance of bacteremia due to Moraxella catarrhalis. 856 49

Respiratory infections are challenging for clinicians and new microbes or those considered previously as normal flora or less virulent forms seen responsible for some cases. Thus, the case reported here is a nosocomial pneumonia caused by Corynebacterium pseudodiphteriticum in a man suffering chronic obstructive pulmonary disease and resolved with cefotaxime. This microorganism is part of the oropharingeal bacterial flora and is therefore associated mainly with respiratory disease an less commonly with endocarditis, prostheses or wound infections. Susceptibility testing found uniform susceptibility to b-lactamases, aminoglycosides, rifampin and tetracycline. Susceptibility to ciprofloxacine is variable and resistance to macrolides (erythromycin and clindamycin) was frequent.
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PMID:[Pneumonia caused by Corynebacterium pseudodiphteriticum, an entity worth knowing]. 1242 Jun 32

Over an 18 month period Streptococcus suis type 2 was isolated in pure or mixed culture in 19 disease outbreaks in pigs. Morbidity and case fatality were variable. Clinical signs were of a nervous or respiratory disease or of death with no premonitory signs. Gross and microscopic findings included one or more of fibrinous polyserositis, fibrinous or hemmorhagic bronchopneumonia, purulent meningitis, myocardial necrosis, focal myocarditis and valvular endocarditis. Brain, cerebrospinal fluid and lung were most reliable sites for isolation of the organism.
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PMID:Streptococcus suis Type 2 Infection in Swine in Ontario: A Review of Clinical and Pathological Presentations. 1742 23

Since the first description of Bordetella holmesii in 1995, almost 100 publications have contributed to the increasing knowledge of this emerging bacterium. Although first reported to induce bacteremia mainly in immunocompromised patients, it has also been isolated in healthy persons and has shown the capacity to induce pertussis-like symptoms and other clinical entities, such as meningitis, arthritis, or endocarditis. Respiratory diseases are generally less severe than those induced by Bordetella pertussis. However, B. holmesii was found to have a higher capacity of invasiveness given the various infection sites in which it was isolated. The diagnosis is difficult, particularly as it is a slow-growing organism but also because respiratory infections are systematically misdiagnosed as B. pertussis. Treatment is delicate, as its susceptibility to macrolides (prescribed in respiratory infections) and ceftriaxone (used in invasive disease) is challenged. Regarding prevention, there is no consensus on prophylactic treatment following index cases and no vaccine is available. Epidemiological data are also sparse, with few prevalence studies available. In this chapter, we provide an overview of the current state of knowledge on B. holmesii.
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PMID:Bordetella holmesii: Still Emerging and Elusive 20 Years On. 2722 92