Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Actinobacillus actinomycetemcomitans is a rare cause of infection in humans. It has been mainly reported in cases of endocarditis and destructive periodontal disease. This report describes the case of a 51-year-old female who had an acute onset of anterior iridocyclitis, followed by the appearance of a white nodule on the lens and subsequent involvement of the vitreous. The course of the disease was long and insidious. Actinobacillus actinomycetemcomitans was isolated from 3 of 26 blood cultures drawn over a period of 40 days, and also from the vitreous. The patient had been suffering from periodontal disease for 3 months prior to her admission. Only two cases of endophthalmitis presumably caused by this organism have previously been reported, but the organism has never been recovered from the eye. This report presents the first case of culture-proven Actinobacillus actinomycetemcomitans endophthalmitis following destructive periodontal disease.
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PMID:Endogenous endophthalmitis caused by Actinobacillus actinomycetemcomitans. 349 54

The review presented here covers metastatic local and systemic disease secondary to the accumulation of plaque or the formation of other pathogenic microbial depots in the mouth. At least 3 pathways may link oral infection to secondary disease, to wit metastatic infection due to transient bacteremia, metastatic immunological injury, and metastatic toxic injury. The available evidence is presented and examples are provided. They concern among others such divergent diseases as acute bacterial myocarditis, infective endocarditis, brain abscess, uveitis and iridocyclitis, trigeminal and atypical facial neuralgia, unilateral facial paralysis, fever of "unknown' origin, and neutrophil dysfunction.
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PMID:Plaque and systemic disease: a reappraisal of the focal infection concept. 636 12