Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014118 (endocarditis)
 15,629 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 80-year-old man had acute pancreatitis during the fourth week of antibiotic therapy for enterococcal endocarditis and 12 days after initiation of ketoprofen therapy for osteoarthritis of the hip. Pancreatitis resolved after discontinuance of ketoprofen therapy and while continuing antibiotic therapy for endocarditis. Common causes of pancreatitis were excluded by laboratory testing. Ketoprofen may have been the cause of pancreatitis in this case; we have suggested two possible mechanisms related to prostaglandin inhibition.
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PMID:Acute pancreatitis associated with ketoprofen. 156 50

The purpose of this study was to determine the incidence of death as the initial manifestation of cholelithiasis. Records of patients who died or underwent cholecystectomy for gallstone-related disease at Duke University Medical Center between 1976 and 1985 were reviewed. Thirty patients died, six of whom (20%) had previous episodes of biliary pain and stone documentation. Twenty-four (80%) were asymptomatic (three with previous incidental diagnosis of cholelithiasis). Reason for admission included acute cholecystitis (nine), pancreatitis (eight), biliary pain (six), cholangitis (four), jaundice (one), and endocarditis (one). Three patients died of gallstone complications without surgical intervention; one patient had renal failure and two had septicemia. Other causes of death were: sepsis (seven patients), cardiac failure (six), pulmonary complications (four), renal failure (three), cerebrovascular accident (three), liver failure (two), pancreatitis (one), and gastrointestinal bleeding (one). During this period, 1731 cholecystectomies were performed without mortality. In this group, the patients were younger (50 +/- 8 years vs. 64 +/- 13 years, p less than 0.001), and had a lower incidence of cirrhosis (p less than 0.001) and diabetes (p less than 0.002). The sex ratio was inverted (p less than 0.001). This study demonstrates that death from gallstones is uncommon (three cases per year), as is death from their initial clinical manifestation (1.2%). The risk of death is two- and ninefold higher in patients with acute cholecystitis or acute pancreatitis. Age, cirrhosis, and diabetes are important determinants of outcome.
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PMID:Deaths from gallstones. Incidence and associated clinical factors. 291 58

Candida species other than C. albicans have been implicated as pathogens in intravascular (bloodstream, intravascular devices, endocarditis) and extravascular (arthritis, osteomielitis, endophtalmitis) infections. C. parapsilosis, however, is rarely implicated in intra-abdominal infections (peritonitis during peritoneal dialysis, complicating surgery or solid-organ transplantation). We describe a case of a 48-y-old male with acute pancreatitis who had a pancreatic abscess produced by primary C. parapsilosis infection. Although he received adequate treatment with antifungal medication and surgical drainage, the outcome was fatal. Because the clinical findings are indistinguishable from bacterial abscesses, Candida species should be considered in cases of complicated pancreatitis, in order to establish a prompt adequate treatment.
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PMID:Pancreatic infection with Candida parapsilosis. 1052 85

The Ross procedure has shown superior hemodynamic results in young patients with aortic root pathology. Wider application of the procedure is restricted by its technical complexity and potential associated problems. The mortality/morbidity associated with 130 consecutive patients who have had the Ross procedure using the root replacement implantation technique between October 29, 1990, and October 8, 1998 is summarized. New York Heart Association (NYHA) preoperatively was class I, 23.5%; class II, 64.7%; and class III, 11.8%; mean age was 36 years (range 3 to 67 years). Men accounted for 73.8% and women 26.2% of the series. Preoperative diagnosis was congenital, 80.7%; rheumatic, 5.3%; failed prosthesis, 7.0%; degenerative, 2.6%; and endocarditis, 4.4% with preoperative aortic insufficiency (AI) 7.9% 1+, 19.8% 2+, 29.7% 3+, and 42.6% 4+, respectively. At operation mean cross-clamp time was 201 minutes (range 102 to 280 minutes). Patient follow-up was 99.2% (1 patient lost to follow-up), and 94.4% were NYHA class I at follow-up and 5.6% class II. Postoperative AI was 0 to 1 + in 93.6% and 2+ or greater in 6.4%. Mean time to patient follow-up was 436 days (range, 20 days to 2,878 days). Thirty-day mortality rate was 1.5%; one patient died of mediastinal bleeding, and one from complications of acute pancreatitis. There was no late mortality. Early autograft explant occurred in one patient secondary to iatrogenic injury to the pulmonary autograft at the time of harvesting, and one late explant occurred secondary to proximal suture line dehiscence. Late autograft repair occurred in one patient secondary to a false aneurysm along the proximal suture line; one patient was reoperated for left main coronary stenosis relative to iatrogenic injury at the time of the procedure. Right ventricular outflow tract replacement has occurred in two patients. Postoperative morbidity and mortality for the Ross procedure, as shown in this series, remains low and supports broader application of the procedure.
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PMID:Critical analysis of the Ross procedure: do its problems justify wider application? 1066 Jan 67

We present a case of suspected linezolid toxicity in a 34-year-old man with sickle cell disease and line-related vancomycin-resistant enterococcal bacteremia and tricuspid valve endocarditis. The patient developed sudden-onset hypoglycemia, lactic acidosis, and acute pancreatitis 11 days after initiation of linezolid. All adverse effects quickly resolved with drug cessation. The pathophysiology underlying this triad of linezolid toxicity is unclear, but may be related to mitochondrial dysfunction.
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PMID:A triad of linezolid toxicity: hypoglycemia, lactic acidosis, and acute pancreatitis. 2642 43

Acute splenic infarcts classically present with left upper quadrant pain, but may be discovered incidentally in many hospitalized patients with otherwise vague complaints. The purpose of our study was to document causes or predisposing conditions in patients found to have acute splenic infarctions on imaging. Following IRB approval, a retrospective review of an imaging database from May 2008 to May 2015 was performed for cases of acute splenic infarctions. The electronic medical record was then reviewed for potential predisposing factors or known causes. Specific note was made of cases with active malignancy, vascular disorders, or inflammatory conditions with an increased risk of vasculopathy. Echocardiogram and electrocardiogram results were reviewed when available. One hundred twenty-three patients with acute splenic infarcts were identified, 65 female and 58 male. The average age was 57 years (range of 22 to 88). Active malignancy was present in 40 patients or 33 %. The most common malignancy in patient with nontraumatic splenic infarctions was pancreatic cancer, present in 16 patients (13 %). In these patients, splenic infarction was due to direct invasion of vessels in the splenic hilum. Acute pancreatitis (severe) was directly responsible for splenic infarction in seven additional cases (6 %). Additional visceral infarcts were present in 18 patients (15 %), most commonly concomitant hepatic or renal infarcts. Documented atrial fibrillation was present in 12 patients, but only 2 cases of left-sided cardiac thrombi were seen on CT (1 atrial, and 1 ventricular thrombus). Eight cases of endocarditis with valvular vegetations were documented on echocardiography (7 %). Splenomegaly was present in 32 patients (26 %) with acute splenic infarction. In patients with nontraumatic splenic infarctions, there appears to be a relatively high association with active malignancy (up to a third of patients). Pancreatic disorders, malignant and inflammatory, also appear to be an important cause of splenic infarction, presumably due to the close proximity of the pancreas to the splenic vessels.
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PMID:Acute nontraumatic splenic infarctions at a tertiary-care center: causes and predisposing factors in 123 patients. 2679 23