Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0014070 (
encephalomyelitis
)
13,017
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
ILDR2
is a member of the Ig superfamily, which is implicated in tricellular tight junctions, and has a putative role in pancreatic islet health and survival. We recently found a novel role for
ILDR2
in delivering inhibitory signals to T cells. In this article, we show that short-term treatment with
ILDR2
-Fc results in long-term durable beneficial effects in the relapsing-remitting experimental autoimmune
encephalomyelitis
and NOD type 1 diabetes models.
ILDR2
-Fc also promotes transplant engraftment in a minor mismatch bone marrow transplantation model.
ILDR2
-Fc displays a unique mode of action, combining immunomodulation, regulation of immune homeostasis, and re-establishment of Ag-specific immune tolerance via regulatory T cell induction. These findings support the potential of ILDR-Fc to provide a promising therapeutic approach for the treatment of autoimmune diseases.
...
PMID:ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance. 2943 90
