Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0014070 (
encephalomyelitis
)
13,017
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An antigen non-specific suppressor factor (
SF4
) produced by a permanent mouse T cell line inhibits the mitogen- and antigen-induced proliferation of cells in vitro. The suppression of immune response is not restricted by interspecies barrier. Administration of the
SF4
factor in vivo had a significant suppressive effect on the induction and manifestation of experimental allergic
encephalomyelitis
(EAE) in rats. Rats treated with
SF4
factor, the first dose being injected on the day of EAE induction, had no clinical manifestations or developed only mild clinical signs of EAE. Administration of the
SF4
starting on day 4 after EAE induction, when the immune system had been activated, depressed the course of EAE. The results obtained in this model autoimmune disease indicate that the described suppressor factor is active in vivo and that it may be used to depress the autoaggressive immune reactions.
...
PMID:Suppression of experimental allergic encephalomyelitis in rats by suppressor factor from a permanent T cell line. 348 25
