Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014070 (encephalomyelitis)
 13,017 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experimental allergic encephalomyelitis (EAE) was induced in female rats and a comparison of the effects of melengestrol acetate (MGA) and hydrocortisone acetate (HCA) was made. A dose response relation was observed. 2-4 mg MGA/kg/day delayed onset of the disease and 16 mg/kg/d ay for 19 days completely inhibited the disease. 20 mg HCA was comparable to 2-4 mg MCA in effectiveness. To determine if MCA or HCA could arrest or reverse the established disease, 25 mg MCA/kg or 125 mg HCA/kg were administered weekly beginning between 7 and 24 days postsensitization. When dosing was started up to 16 days postsensitizat ion, MGA was more effective than HCA, however when started at 24 days, little difference between the 2 was noted. Some reversal of disease was noted when a single dose of MCA (100 mg/kg) or HCA (500 mg/kg) was given 16, 20 or 24 days postsensitization. It was concluded that both MGA and HCA prevented the development of EAE and reversed the established disease. MCA was considered superior to HCA in both prophylactic and therapeutic treatment.
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PMID:A comparison of the effects of melengestrol acetate and hydrocortisone acetate on experimental allergic encephalomyelitis in rats. 544 6