Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014070 (encephalomyelitis)
 13,017 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This paper assesses reactive gliosis in the optic tracts and other regions of brain in Lewis rats with experimental autoimmune encephalomyelitis (EAE). Enhanced immunostaining for glial fibrillary acidic protein (GFAP) in brains from rats with EAE occurred primarily in the white-matter tracts and was not restricted to sites of inflammation. Immunocytochemical staining for other putative astrocytic antigens demonstrated glutathione-S-transferase (Yb isoenzyme) to be localized extensively in GFAP-positive cells and vimentin to be present both in inflammatory cells and in some GFAP-positive astroglial cells. Positive staining for carbonic anhydrase and glutamine synthetase was observed in oligodendrocytes. In the optic tracts glutamine synthetase, but not carbonic anhydrase, was also observed in some astrocytes.
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PMID:Reactive gliosis in the brains of Lewis rats with experimental allergic encephalomyelitis. 197 May 78

Spinal cord sections from rats sensitized to develop experimental allergic encephalomyelitis (EAE) were immunostained with antibodies against glial fibrillary acidic protein (GFAP), carbonic anhydrase, and vimentin, to see whether the latter two antigens could be detected in GFAP-positive reactive astrocytes. Sixteen days after sensitization (16 dpi) there was intense carbonic anhydrase immunostaining in GFAP-positive cells in the spinal cords of EAE rats, particularly in the white matter. At 13 and 20 dpi carbonic anhydrase immunostaining in astrocytes was less intense, and in the spinal cord white matter of control animals carbonic anhydrase was not detected in the few GFAP-positive cells. In the spinal cords of EAE rats vimentin immunostaining was observed in inflammatory cells and astrocytes. In the latter, GFAP and carbonic anhydrase were colocalized with vimentin. The data suggest that carbonic anhydrase expression in astrocytes is an acute response to injury and that vimentin can be detected in astrocytes, as well as inflammatory cells, as early as 16 dpi.
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PMID:Gliosis in the spinal cords of rats with experimental allergic encephalomyelitis: immunostaining of carbonic anhydrase and vimentin in reactive astrocytes. 252 21