Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0014070 (
encephalomyelitis
)
13,017
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cathepsin K
was originally identified as an osteoclast-specific lysosomal protease, the inhibitor of which has been considered might have therapeutic potential. We show that inhibition of
cathepsin K
could potently suppress autoimmune inflammation of the joints as well as osteoclastic bone resorption in autoimmune arthritis. Furthermore,
cathepsin K
-/- mice were resistant to experimental autoimmune
encephalomyelitis
. Pharmacological inhibition or targeted disruption of
cathepsin K
resulted in defective Toll-like receptor 9 signaling in dendritic cells in response to unmethylated CpG DNA, which in turn led to attenuated induction of T helper 17 cells, without affecting the antigen-presenting ability of dendritic cells. These results suggest that
cathepsin K
plays an important role in the immune system and may serve as a valid therapeutic target in autoimmune diseases.
...
PMID:Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. 1823 12
