Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014070 (encephalomyelitis)
 13,017 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experimental allergy was induced in animals: asthma, a Type I allergy, was induced in guinea pigs by sensitizing them with alpha-amylase (inhalation), and experimental allergic encephalomyelitis (EAE), a Type IV allergy, was induced in rats. Pulmonary, brain and serum lysosomal enzyme activities were measured in normal and allergic conditions. beta-Glucuronidase (beta-G) and arylsulfatase (AS) activities were determined by the fluorescent technique. During the asthmatic attack, pulmonary lysosomal enzyme activities were not different from that in the normal state in guinea pigs. However, brain lysosomal enzyme activities were elevated markedly on the 1 st day of EAE induction. Brain beta-G activity was elevated on the 2nd day, and AS activity had a tendency to be increased. On the other hand, serum lysosomal enzyme activity was not altered significantly. In the experimental allergy, lysosomal enzyme activity was altered in Type IV, but not in Type I.
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PMID:[Changes of lysosomal enzyme activities in experimental type I and type IV allergic models]. 398 68

There is a need for novel drugs for the treatment of infectious diseases, autoimmunity and cancer. Cyclic peptides constitute a class of compounds that have made crucial contributions to the treatment of certain diseases. Penicillin, Vancomycin, Cyclosporin, the Echinocandins and Bleomycin are well-known cyclic peptides. Cyclic peptides, compared to linear peptides, have been considered to have greater potential as therapeutic agents due to their increased chemical and enzymatic stability, receptor selectively, and improved pharmacodynamic properties. They have been used as synthetic immunogens, transmembrane ion channels, antigens for Herpes Simplex Virus, potential immunotherapeutic vaccines for diabetes and Experimental Autoimmune Encephalomyelitis - an animal model of Multiple Sclerosis, as inhibitors against alpha-amylase and as protein stabilizers. Herein, we review important cyclic peptides as therapeutic agents in disease.
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PMID:Round and round we go: cyclic peptides in disease. 1691 50