Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014070 (encephalomyelitis)
 13,017 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Less pronounced intensity of extrapyramidal hyperkineses and aggravation of motor disturbances in patients with diffuse sclerosis occurring under the effect of tegretol prompted the authors to study the action of this drug on the course of experimental allergic encephalomyelitis. Daily administration of tegretol in a dose of 375 mg/kg retarded the development of the affection and produced a marked adynamia in the animals. Slowing down of the dominant rhythm and depression of its amplitude were recorded on the EEG. Shifts in the potassium and sodium content and reduced brain cholesterase activity were noted. The authors ascribe these changes to a mediated action of tegretol upon deep-seated cerebral structures.
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PMID:[Study of the mechanism of action of tegretol in experimental allergic encephalomyelitis]. 122 93

Cholesteryl ester hydrolase and cholesteryl esters were measured in brain homogenates from rats in various stages of experimental allergic encephalomyelitis (EAE), a model for multiple sclerosis, and in age-matched controls. Cholesteryl esters were elevated approximately 280-507% in EAE rats with clinical indices of 1-3, corresponding to increasing severity of symptoms, but were not significantly different from controls upon disappearance of symptoms during the recovery period (stage = R2). Cholesteryl ester hydrolase declined progressively 12-34% during stages 1-3, rebounded to a level 16% greater than controls during the initial stage of recovery (R1) and remained significantly elevated by 6% over controls upon disappearance of symptoms (R2). A highly significant (P less than 0.001) correlation of reduction in cholesteryl ester hydrolase activity with clinical index was confirmed by linear regression analysis (R = 0.91). It is concluded that a decline in cholesteryl ester hydrolase activity is an early event in EAE which leads to accumulation of cholesteryl esters and may play a role in induction and progression of this demyelinating disorder.
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PMID:Decline in cholesteryl ester hydrolase activity of rat brain with progress of experimental allergic encephalomyelitis followed by rebound during recovery. 188 9