Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014070 (encephalomyelitis)
 13,017 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pathogenicity of hemagglutinating encephalomyelitis virus isolated from the brain of each of 5 pigs with clinical signs and microscopic lesions of encephalomyelitis (1 pig from each of 5 naturally infected herbs) was tested under experimental conditions. Each isolant was administered intranasally to 5 neonatal pigs. Clinically affected pigs developed either an acute or chronic form of illness, commencing 4 to 8 days after exposure. Listless, inappetence, and vomiting were clinical signs common to both forms. Additional signs of the acute form were paddling, muscle tremors, and hyperesthesia. Additional signs of the chronic form were loss of condition and either loss of weight or failure to gain weight at a rate similar to nonaffected littermates.
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PMID:Pathogenicity of field isolants of hemagglutinating encephalomyelitis virus for neonatal pigs. 124 57

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a newly recognized autoimmune central nervous system (CNS) inflammatory disorder, presenting with an array of neurological symptoms in association with autoantibodies against GFAP, a hallmark protein expressed on astrocytes. Limited knowledge is available on the disease pathogenesis and clinical outcome. Here, we report a case of autoimmune GFAP astrocytopathy presenting with encephalomyelitis and parkinsonism. Our patient was a 66-year old male who experienced progressive somnolence, apathy, anxiety, right arm tremor, urinary retention, progressive weakness, and falls over the course of three months, followed by acute delusional psychosis. His neurologic exam on hospital admission was notable for cognitive impairment, myoclonus, rigidity, right hand action tremor, bradykinesia, shuffling gait, and dysmetria. Cerebrospinal fluid examination showed elevated protein, lymphocytic pleocytosis, and one unique oligoclonal band. Magnetic resonance imaging (MRI) revealed non-specific T2/FLAIR hyperintensities in the brain and longitudinally extensive transverse myelitis in the cervical spine. FDG-PET showed a pattern of brain uptake suspicious for limbic encephalitis. Serum and CSF paraneoplastic panel showed presence of GFAP immunoglobulin G (IgG). Treatment with corticosteroids resulted in clinical and radiographic improvement. However, the patient was treated with anti-CD20 immunotherapy due to steroid-dependence. This case exemplifies the recently described neurologic syndrome of autoimmune GFAP astrocytopathy presenting with encephalomyelitis and parkinsonism, reversed by B lymphocyte depletion.
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PMID:A case of GFAP-astroglial autoimmunity presenting with reversible parkinsonism. 3188 22