Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0014070 (encephalomyelitis)
 13,017 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is suggested that disturbances of excitation velocity in optic nerve disease go along with a temporal heterogenity of impulse conduction which subsequently may be responsible for an increased variability of latencies of cortical visual evoked potentials. Since the latencies of each single evoked response, being superimposed by EEG-background activity, cannot be measured, we developed a computer-assisted statistical technique in an attempt to quantify this variability. Random samples (n = 30) were taken from the whole of stimulus-correlated EEG-segments recorded during a clinical routine examination (n = 200) and averaged to give a number (n = 30) of randomly sampled VEP's. The results of the statistical analysis, by calculating the variability of the latency values of these samples, can be taken as an approximation of the real variability of latency of single evoked potentials. It could be demonstrated that the variability of latency of the first clearly defined positive component P2 of the pattern-induced VEP is increased even in cases of clinically suspected retrobulbar neuritis or disseminated encephalomyelitis, where the summed VER-latency turned out to be within normal limits. Based upon these results, the statistical analysis proposed here has proven to be of differential diagnostic significance as an additional parameter - besides the ordinary measurement of latency - especially in borderline cases.
 ...
PMID:[Statistical VEP analysis for approximate determination of latency distribution of visually evoked single cortical stimulus responses]. 643 17

After repeated immunization against european spring-summer encephalitis, a 36-year-old patient developed recurrent retrobulbar neuritis, had a fit of grand mal epilepsy and a focal motor clonic-tonic attack status as a result of post-vaccination ADEM. Post-vaccination encephalomyelitis after TBE-vaccination is a very rare complication of vaccination and has so far only been described occasionally. We observed the clinical course of post-vaccination ADEM after TBE vaccination over 12 years.
 ...
PMID:[Acute disseminated encephalomyelitis after active immunization against early summer encephalitis]. 1530 8

The Yaroslavl region is an endemic area for Lyme disease (LD) with one of the highest levels of morbidity in Russia. Chronic neuroborreliosis can mimic multiple sclerosis and cause considerable difficulties in differential diagnosis. A comparative clinical-instrumental analysis of patients with definite multiple sclerosis (n=65) and chronic borrelial encephalomyelitis (n=11) was carried out. The key differential-diagnostic features of multiple sclerosis and borrelial encephalomyelitis were specified. Migrating erythema and tick's bite in the anamnesis, combined with lesions of the central and peripheral nervous systems, the absence of retrobulbar neuritis in the anamnesis, artralgia and myalgia, the high blood sedimentation rate were not characteristic of multiple sclerosis. A patient with abovementioned findings should be tested for the presence of antibodies to Borrelia burgdorferi in the blood serum and, if necessary, in the cerebrospinal fluid to exclude the diagnosis of Lime disease.
 ...
PMID:[Differential aspects of multiple sclerosis and chronic borrelial encephalomyelitis]. 2194 65