Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0014070 (encephalomyelitis)
 13,017 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ultrastructure of visna, a slowly progressive menigo-encephalomyelitis of sheep, was studied in animals sacrificed one month after intracerebral inoculation of visna virus. The major pathological changes, representative of those seen during the first year after infection, consist of inflammation and minor focal destructive lesions of grey and white matter. The inflammatory infiltrates, both subependymal and perivascular as well as of the choroid plexus, were composed mainly of lymphocytes and macrophages with varying numbers of plasma cells. The demyelination seen was of the secondary or Wallerian type. There was no evidence of primary demyelination. Visna virions were not seen in any of the CNS material studied. The ultrastructural findings are compatible with the view that lesions in visna may be induced by a cell-mediated immune response. However, changes characteristic of an autoimmune reaction to myelin antigens were not observed.
 ...
PMID:The ultrastructure of early visna lesions. 19 37

In the history of experimental demyelination, allergic encephalomyelitis (EAE) is the most impressive experimental demyelinating disease based on an immunological mechanism. The evolution of the neuropathological process of chronic EAE is very close to that of chronic Multiple Sclerosis. On the other hand experimental inoculation of different viruses can induce various types of demyelination depending on the main target of the virus and the host response, this latter being conditioned by the age, the mechanism of immunity and the persistence of the virus in the brain. The demyelination can be induced by a viral persistent infection primarily affecting oligodendrocytes (CDV, JHM hepatitis virus) or acting through an immunomediate response against myelin (Visna, Theiler virus, human conventional viruses). The experimental demyelinating models show that also in Multiple Sclerosis a viral etiology could be the starting point of a demyelinating process based on a immunologically mediated mechanism.
 ...
PMID:Experimental patterns related to multiple sclerosis pathology. 331 66