Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014070 (encephalomyelitis)
 13,017 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Murin Cerebral Malaria (MCM) with Plasmodium berghei ANKA and the CBA/Ca mice is the result of an immunopathological process. An overproduction of TNF is implicated in its pathogenesis. Recent datas concerning TNF production during the course of Plasmodium vinckei vinckei infection, and analysis of relationships between MCM and Experimental Allergic Encephalomyelitis (EAE) raise the hypothesis of the involvement of an auto-immune process in the murin disease. The role of cellular immunity in human cerebral malaria remains obscure. Cytokines could majore adherence of parasitized red blood cells to cerebral endothelial cells.
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PMID:[Involvement of cellular immunity in pathology. Neuromalaria]. 132 51

Several neurological complications are associated with severe falciparum malaria. Cerebral malaria is one of the most life-threatening complications. A few patients may experience a neurological syndrome after complete recovery from Plasmodium falciparum infection. In the literature especially the postmalaria neurological syndrome (PMNS), acute disseminated encephalomyelitis (ADEM) and delayed cerebellar ataxia have been reported. We describe a case of a 53-year-old woman who was readmitted after an adequately treated P. falciparum infection with word-finding difficulties, confusion and tremor. Peripheral blood smears were repeatedly negative for malarial parasites. The clinical features best fitted a PMNS. Because of the severity of the syndrome she was treated with high-dose prednisone. She recovered completely. The possibility of ADEM is also discussed. Aetiology of these syndromes is still unknown, but it could be mediated by an immunological mechanism. PMNS or ADEM must be considered when neurological signs and symptoms occur after recovery from a P. falciparum infection.
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PMID:Neurological complications following Plasmodium falciparum infection. 1595 88