Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014070 (encephalomyelitis)
 13,017 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The neuropathologic study of a 7-month-old female patient affected by familial erythrophagocytic lymphohistiocytosis (FEL) reveals three main features: (1) a lymphohistiocytic leptomeningitis with erythrophagocytosis; (2) perivascular lymphohistiocytic cuffs in the cerebral and cerebellar white matter and, to a lesser extent, in the thalamus, the reticular formation of the brain stem and the griseum pontis; (3) perifocal gliosis and demyelination, especially in the cerebellar white matter. The lesions remind of the perivenous post-infectious encephalomyelitides. Perifocal demyelination has been reported in FEL very seldom. Although its pathogenesis is not known, immune mechanisms could play a role by analogy with perivenous encephalomyelitis.
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PMID:Familial erythrophagocytic lymphohistiocytosis. A neuropathologic study. 401 68

The histopathologic and virologic features of several mouse strains inoculated with the C strain of lactate dehydrogenase-elevating virus are described. Young C58 and AKR mice were found to develop histologic poliomyelitis when injected with cyclophosphamide prior to peripheral inoculation of lactate dehydrogenase-elevating virus. None of the C58 mice developed serious hindlimb paralysis, but some of the AKR mice did. Chronic poliomyelitis persisted for many weeks after infection in some C58 mice, but a spongioform poliomyopathy of the anterior horn was found in others. In contrast, inoculation of young C57BR/cd mice with lactate dehydrogenase-elevating virus produced inflammatory lesions restricted to central nervous system white matter that could be detected many weeks after infection. The most frequent findings were moderate leptomeningitis and myelitis localized to the white matter, however, radiculitis was also occasionally observed. Severe necrosis of spinal cord white matter was seen rarely. Development of lesions in C57BR/cd mice did not require immunosuppression prior to peripheral inoculation with virus and was not age related, sex linked, or exclusively controlled by the H-2 histocompatibility locus. Lactate dehydrogenase-elevating virus-infected C57L, C57BL/6, and RF mice did not develop poliomyelitis; however, C57L and C57BL/6 mice displayed a low incidence of mild encephalomyelitis. Poliomyelitis-susceptible C58 mice had the highest levels of viral infectivity in plasma and central nervous system tissues. White matter disease-susceptible C57BR/cd mice had viral titers in plasma and central nervous system tissues comparable to poliomyelitis-resistant C57L, C57BL/6, and RF mice. These studies demonstrate that different strains of mice have differing susceptibilities to the development of central nervous system inflammatory diseases.
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PMID:Mouse strain-specific central nervous system lesions associated with lactate dehydrogenase-elevating virus infection. 688 86

An outbreak of eastern equine encephalomyelitis (EEE) occurred in Michigan free-ranging white-tailed deer (Odocoileus virginianus) during late summer and fall of 2005. Brain tissue from 7 deer with EEE, as confirmed by reverse transcriptase polymerase chain reaction, was studied. Detailed microscopic examination, indirect immunohistochemistry (IHC), and in situ hybridization (ISH) were used to characterize the lesions and distribution of the EEE virus within the brain. The main lesion in all 7 deer was a polioencephalomyelitis with leptomeningitis, which was more prominent within the cerebral cortex, thalamus, hypothalamus, and brainstem. In 3 deer, multifocal microhemorrhages surrounded smaller vessels with or without perivascular cuffing, although vasculitis was not observed. Neuronal necrosis, associated with perineuronal satellitosis and neutrophilic neuronophagia, was most prominent in the thalamus and the brainstem. Positive IHC labeling was mainly observed in the perikaryon, axons, and dendrites of necrotic and intact neurons and, to a much lesser degree, in glial cells, a few neutrophils in the thalamus and the brainstem, and occasionally the cerebral cortex of the 7 deer. There was minimal IHC-based labeling in the cerebellum and hippocampus. ISH labeling was exclusively observed in the cytoplasm of neurons, with a distribution similar to IHC-positive neurons. Neurons positive by IHC and ISH were most prominent in the thalamus and brainstem. The neuropathology of EEE in deer is compared with other species. Based on our findings, EEE has to be considered a differential diagnosis for neurologic disease and meningoencephalitis in white-tailed deer.
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PMID:Distribution of eastern equine encephalomyelitis viral protein and nucleic acid within central nervous tissue lesions in white-tailed deer (Odocoileus virginianus). 2368 67