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Query: UMLS:C0013911 (emaciation)
 1,059 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pathogenicity of the Lister (Elstree) strain, a vaccinia virus, in rabbits after intravenous injection was studied by histopathological and immunofluorescent methods. Inoculation of 1 X 10(7) PFU (pock-forming unit) virus into weanling and young adult rabbits caused severe emaciation and high mortality within 2 weeks. Pathological findings were characterized by vesicular lesions along muco-cutaneous junction areas of the eyes, nose and mouth and by inflammatory changes in the brain, mainly in the meninges and choroid plexus. Immunofluorescent staining of the tissues of animals sacrificed at intervals demonstrated the accumulation of vaccinia viral antigen (s) in the loci of pathological changes. The suitability of this model system for the study of pathogenesis of human postvaccinal meningoencephalitis is discussed.
Jpn J Med Sci Biol 1977 Dec
PMID:Pathogenicity of a vaccine strain of vaccina virus in rabbits administered by intravenous route. 2 30

Ovine progressive pneumonia, a chronic, insidious disease of adult sheep, has a relentless course leading to dyspnea, emaciation, and death. Clinical observations and serologic tests are adequate for making a tentative diagnosis. The agar gel immunodiffusion test seems to be the best serologic procedure for indicating infection with the virus but cannot be used to predict morphologic changes or clinical disease, inasmuch as many clinically unaffected animals carry the virus. A definitive diagnosis is based on finding lesions and isolating virus. Affected lungs are large and heavy as a result of interstitial accumulation of lymphoid cells and fibromuscular tissue. Frequently, interstitial lesions are accompanied by bronchopneumonia from secondary bacterial infection. The causal virus can be isolated from infected lungs by cocultivation with primary ovine or bovine cells.
J Am Vet Med Assoc 1978 Dec 15
PMID:Diagnostic features of ovine progressive pneumonia. 21 18

The ultimate object of all types of dietary management before the introduction of insulin was to prevent emaciation and death: the consequences of metabolic derangements due to lack of insulin. Now, while dietary therapy continues to be important in minimizing the requirement for endogenous insulin or in balancing administered insulin, the major objects are changing to prevention of large vessel and microvascular disease. The next decade will probably see a more widespread introduction of diets containing a lower proportion of energy derived from fat. The increased carbohydrate intake will almost inevitably result in increased dietary fibre intake. Whether David Jenkins' Lente carbohydrate foods (those containing viscous unabsorbable polysaccharides) will prove to be of lasting value is not yet known. Since galactomannans occur in legumes perhaps we should consider the possibility of diets containing large proportions of legumes: a twentieth century 'Legume cure'? If this should prove of value it would not have excited ancient Indian physicians who wrote (in the Caraka-Samita) of their use of legumes in the treatment of glycosuria, at least as early as the first century AD, before Aretaeus had applied the term diabetes.
Proc Nutr Soc 1979 Dec
PMID:The dietary management of diabetes in adults. 39 52

A colony of nude mice was maintained under controlled standards of care for 12 months, at which time a rapidly escalating liver disease developed in the animals, characterized by jaundice, emaciation, and rapid death. Histologically, the livers had swollen, vacuolated hepatic cells and increased numbers of enlarged Kupffer cells. Mouse hepatitis virus was not isolated from the livers of sick mice. Although the nature of the lesions suggested toxicity, efforts to reproduce the lesions by increased exposure to chemical compounds used for colony husbandry were unsuccessful. A definitive determination of the causative agent was not made.
Lab Anim Sci 1978 Dec
PMID:Hepatic jaundice in a colony of nude mice. 75 Jul 31

A spontaneous infection with Schistosoma mansoni was found in a chimpanzee (Pan troglodytes versus) recently imported from Sierra Leone, Africa. Clinical signs consisted of anemia, liver enlargement, bronchial rales, and emaciation. The primary gross pathologic lesions included a fibrotic firm nodular liver and pulmonary edema and consolidation. Histopathologic examination revealed changes similar to the experimental syndrome of Manson's schistosomiasis in the chimpanzee. The diagnosis was confirmed by the presence of the eggs and larvae of Schistosoma mansoni.
Lab Anim Sci 1975 Dec
PMID:A natural case of Schistosoma mansoni in the chimpanzee (Pan troglodytes versus). 120 45

Mange caused by Sarcoptes scabiei var. vulpes appeared among red foxes (Vulpes vulpes) in Scandinavia (south-west Finland) for the first time in this century in 1967. The disease was most probably introduced by foxes crossing the Gulf of Finland from Estonia. The mange epizootic spread northwards through Finland and reached Sweden in late 1975, when mangy foxes appeared in the northern part of the country. In 1984, mange was observed in most parts of Sweden. The disease was observed to spread rapidly in boreal areas, whereas it spread more slowly in agricultural areas. Mortality due to mange was very high. The duration of the disease before death due to emaciation has been shown experimentally to be over 90 days. An outbreak of fox mange among Arctic foxes (Alopex lagopus) occurred in 1986. The local population of Arctic foxes was caught and successfully treated. The following year, treated foxes were caught again and no signs of disease were found. Sporadic cases of fox mange have also been diagnosed in lynx (Lynx lynx), pine marten (Martes martes) and domestic dogs. Single cases have been observed in other species: wolf (Canis lupus), mountain hare (Lepus timidus), domestic cat and horse. No cases of sarcoptic mange have been recorded in the badger (Meles meles). At present, although fox mange occurs as an epizootic in local populations, the number of foxes has increased again in many parts of Sweden.
Rev Sci Tech 1992 Dec
PMID:Sarcoptic mange in Swedish wildlife. 130 57

A 69-year-old-female with a history of rheumatoid arthritis since 1975 had suffered from dysesthesia of extremities since October 1989. Radiating pain and weakness occurred when she tried to stand up on Dec. 25 in 1989. She was admitted to our hospital in October 1990. Physical examination showed emaciation, hypesthesia of extremities, hypesthesia over the right chest and back, impaired vibration and position sense, and hyperreflexia. Laboratory findings revealed that the erythrocyte sedimentation rate was elevated to 46mm/hr, rheumatoid factor (RF) to 83.1IU/ml and CRP to 3.7mg/dl. Her blood sugar was high and she was diagnosed as having diabetes mellitus. Cervical X ray film showed atlanto-axial subluxation. A pseudotumor around the odontoid process bulging into the spinal canal and compression of the upper cervical cord was observed by MRI. In spite of administration of bucillamine (100mg/day), the size of pseudotumor did not change. Methotrexate (MTX) at a dose of 5mg/week was started in February 1991 and the pseudotumor decreased in size with a concurrent reduction of ESR, RF and CRP. However, the high intensity lesion by T2 weighed image did not change and dysesthesia persisted. The pseudotumor was thought to be due to pannus and it was revealed that MTX was effective for reduction. The persistent dysesthesia was probably due to the degeneration of the upper cervical cord, although diabetic neuropathy may also have played a role.
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PMID:[A case of rheumatoid arthritis complicated with pseudotumor around odontoid process successfully treated by methotrexate]. 144 85

An infection with Ollulanus tricuspis was found in three cats with hypertrophic gastritis. Two cats were put down because of chronic vomiting and emaciation. The third cat died shortly after the appearance of blood in its vomit and faeces.
Tijdschr Diergeneeskd 1992 Dec 15
PMID:[3 cases of hypertrophic gastritis associated with a Ollulanus tricuspis infection in cats]. 148 Nov 95

In order to confirm the clinical and histological diagnosis of scrapie and to determine the infectivity titer of the scrapie agent in the brain of a naturally infected Suffolk sheep, 123 white Swiss mice were inoculated intracerebrally. From about 13 to 20 months post-inoculation, 28 mice died, and 95 that were sick were killed. In the terminal stages of disease, the mice developed weakness, gradual emaciation, posterior ataxia, and occasionally alopecia. The average infection (83%) of mice affected with scrapie occurred in groups 1 to 4 inoculated with dilution 10(-1) to 10(-4) of scrapie sheep brain. Sixty-seven (54.5%) of the mice developed spongiform lesions and vacuolar degeneration of neurons. Similarities of scrapie with other subacute spongiform encephalopathies in animals and humans are discussed.
Zentralbl Veterinarmed B 1990 Dec
PMID:Experimental scrapie in white Swiss mice. 208 31

In order to clarify the toxicity of the antineoplastic drugs, bleomycin (BLM), peplomycin (PEP) and cis-diamminedichloroplatinum (CDDP), which are commonly used to treat head and neck cancer by simultaneous administration, the semiacute toxicity of each of these drugs in rats was studied as an initial step. Body-weight change, general behavior, red blood cell count (RBC), white blood cell count (WBC), serum biochemistry (s-GOT, s-GPT, BUN, GLU, ALB, TP), A/G ratio, relative organ weight and histopathological features were determined. BLM and PEP given by ip administration once a week produced severe diarrhea, decreased diet consumption, emaciation, piloerection and loss of hair, enhancements of RBC and WBC, several changes in serum biochemistry, proliferation and mitosis of epithelial cells in the forestomach and occasional granular and vacuolar degeneration in the liver. CDDP administered in the same manner produced a significant decrease of WBC, several changes in serum biochemistry parameters especially BUN, an increased focal-segmental mesangial matrix in the glomeruli and vacuolar degeneration of epithelial cells of the convoluted tubule of the kidney.
J Nihon Univ Sch Dent 1989 Dec
PMID:A study on the toxicity of antineoplastic drugs (bleomycin, peplomycin and cis-diamminedichloroplatinum) by simultaneous administration (Part 1). 248 79


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