Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013911 (emaciation)
 1,059 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 89-week-old male chicken was presented with signs of depression, emaciation, and weakness. At necropsy, a stricture was found at the ileocecal junction that resulted in blockage and dilation of the ileum proximal to the stricture. Histologically, neoplastic epithelial cells that contained mucin had invaded the intestinal wall and produced a fibrous connective tissue reaction. The lesion was diagnosed as scirrhous intestinal adenocarcinoma.
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PMID:Intestinal adenocarcinoma of the ileocecal junction in a chicken. 141 17

A case of intestinal adenocarcinoma is described in a 4-year-old dairy goat with progressive emaciation. At necropsy, a tumour was found in the middle part of the jejunum as an annular, firm white mass which resulted in stenosis and dilation of the intestine proximal to the lesion. Spread of the tumour, with thickening of the contiguous mesentery, and metastasis to the mesenteric lymph nodes were observed. Microscopically, the tumour was characterized by nests or sheets of mucin-rich cuboid or columnar epithelial cells, which formed irregular acinar structures that infiltrated all layers of the intestinal wall. In the mesentery, neoplastic cells were surrounded by an intense fibrous reaction. A diffuse inflammatory infiltrate of lymphocytes was observed both in the mesentery and in the intestinal layers. These findings are compared with those observed in sheep, in which this type of tumour occurs more frequently.
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PMID:Adenocarcinoma of the small intestine in a goat. 980 31

A diagnosis of adenosquamous carcinoma was made in an 11-year-old red fox. The animal showed emaciation and purulent nasal discharge. Necropsy revealed diffuse thickening of the nasal mucosa and tumours on the soft palate, and there was an oronasal fistula contiguous with the tumours. The nasal and oral lesions were composed of adenocarcinomatous cells and squamous cells, the latter predominating in the oral lesions. The marrow of the palatine bone also contained neoplastic tissue, which consisted of cysts and keratin masses surrounded by well-differentiated squamous cells. Although inconspicuous in the oral cavity and marrow, ciliated cells with or without mucin were observed in the adenocarcinomatous and cystic elements. Neoplastic basal cells and less-differentiated adenocarcinoma cells, which were identifiable by immunolabelling for cytokeratin 5 (CK5) and CK18, were considered to be pluripotential. These cells, which lined tubular structures, were distinct from intermediate cells in mucoepidermoid carcinoma, which can differentiate into squamous and mucin-producing cells but have a nondescript appearance.
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PMID:Adenosquamous carcinoma with cilium formation, mucin production and keratinization in the nasal cavity of a red fox (Vulpes vulpes schrencki). 1764 90