Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013911 (emaciation)
 1,059 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A trotter stallion showing symptoms of emaciation was suspected of disease of the liver associated with cholestasis in view of clinical symptoms (poor appetite, sluggishness, jaundice and oedema) and the results of examination of the blood (increased concentrations of gamma-glutamyl, transpeptidase, sorbitol dehydrogenase, alkaline phosphatase, aspartate aminotransferase and markedly increased conjugated bilirubin). A specimen removed at biopsy of the liver revealed the presence of portal fibrosis and severe cholestasis. At autopsy, it was found that very extensive fibrosis of the pancreas (probably due to migrating larvae of parasites) had caused extrahepatic cholestasis accompanied by fibrosis of the liver. The lesions of the coronary border, which were also present in this horse, could not be accounted for.
 ...
PMID:[Extrahepatic cholestasis due to pancreas fibrosis in a trotter]. 397 93

Chronic fatigue and immune dysfunction syndrome (CFIDS) is a recognized human illness with zoonotic implications that is rarely described in animals. Eight birds of prey examined between 1992 and 1995 and sharing common symptoms (asthenia, inability to fly, poor appetite and emaciation) underwent laboratory tests revealing immunodeficiency, anaemia, high creatine kinase levels and low serum magnesium levels. Diagnosis of CFIDS was based upon these features. The effectiveness of an arsenic-based medication, thiacetarsamide sodium, administered intravenously for 2-3 days at low dosages (0.1 ml/kg/day) has been demonstrated by checks carried out 10, 20 and 30 days after therapy. The symptoms and the immune and haematological dysfunctions disappeared within 2-4 weeks of treatment. In all patients, micrococcus-like organisms found adhering to the outer surface of many red blood cells, had disappeared at post-treatment controls. Two of five blood cultures were positive for Staphylococcus spp. (S. intermedius and S. xilosus). Consideration is given to the pharmacological activity of an arsenic-based drug in animal illnesses resembling CFIDS.
 ...
PMID:Chronic fatigue and immune dysfunction syndrome associated with Staphylococcus spp. bacteraemia responsive to thiacetarsamide sodium in eight birds of prey. 1512 82

Nutritional status of children is a global indicator of children's well-being and, indirectly, of the community's well-being. The first objective of this work is to assess the nutritional status of children under five years-old living in a suburb of the city of Lubumbashi, DR Congo, at the end of the 1998-2003 armed conflict. The second objective aims to identify some predictors of malnutrition. A multivariate logistic regression was applied to the results of a cross-sectional survey of 1963 children from selected households. In addition to the anthropometric variables, living conditions were also used. We observed 33.5% stunted growth and 3.8% emaciation. After logistic regression, a low maternal educational level (less than 7 years), the absence of a drinking water tap available in the house or yard, male gender, and age of children ( > 11 months) were all significantly associated with increased risk of stunted growth. Moreover, decreased appetite, diarrhea and age of children ( < 12 months) were significant predictors of emaciation. Compared to the classification of the World Health Organization, our results indicate that the prevalence of stunting is high and the prevalence of emaciation is low. Interventions against malnutrition should consider the various predictors discussed in this study in order to reduce mortality and morbidity in children and contribute to their well-being.
 ...
PMID:[Factors associated with malnutrition in children aged under five years in Lubumbashi (DRC)]. 2136 Aug 63

Green turtles (Chelonia mydas) are unique because hatchlings and pelagic juveniles are carnivorous, whereas later life stages become primarily herbivorous. Although this dietary shift is well understood, nutritional requirements at each developmental stage are not. Diet selection during rehabilitation is challenging, because turtles are often fed high-protein, low-fiber diets to counteract poor appetite and emaciation, which can result in gastrointestinal disorders. The objective of this study was to analyze hematology, plasma biochemistry, and nutritional analytes to determine the effect of diet on rehabilitating green turtle health and recovery. Turtles in rehabilitation at the Georgia Sea Turtle Center (GSTC) on Jekyll Island, Georgia (n = 21) were sampled at admission, mid-rehabilitation, and recovery. Duration of rehabilitation ranged from 48 to 233 days (mean = 117) and included a shift from a mixed seafood-vegetable diet at admission to a primarily herbivorous diet at recovery. For comparison, free-ranging turtles captured during an ongoing monitoring project in St. Lucie County, Florida (n = 34) were evaluated for the same variables. Several analytes improved during rehabilitation, including total protein, uric acid, potassium, and vitamins A and E. Others were significantly different, including higher cholesterol and triglycerides, but lower calcium, vitamin D, and magnesium in recovery compared with freeranging turtles. These variations illustrate the benefits of appropriate supportive care during rehabilitation as well as the importance of a species-specific diet for green turtles, and may facilitate formulation of nutritionally complete gel diets for this species under human care.
 ...
PMID:COMPARISON OF HEMATOLOGICAL, PLASMA BIOCHEMICAL, AND NUTRITIONAL ANALYTES OF REHABILITATING AND APPARENTLY HEALTHY FREE-RANGING ATLANTIC GREEN TURTLES (CHELONIA MYDAS). 3112 Jun 64

Diencephalic syndrome is one of the rare causes of failure to thrive in infants and young children. It is caused by a tumour in diencephalon (thalamus and hypothalamus), characterised by profound emaciation with uniform loss of body weight despite normal or slightly decreased appetite, locomotor hyperactivity, euphoria and visual symptoms. Anaesthetic considerations due to decreased body fat include positioning to avoid pressure necrosis, measures to avoid hypothermia, proper drug dosing, treating electrolyte imbalances and delayed recovery. We report successful anaesthetic management of a child with diencephalic syndrome scheduled for an endoscopic biopsy of suprasellar space occupying lesion under general anaesthesia.
 ...
PMID:Diencephalic syndrome: an anaesthetic challenge. 3128 70

Threatened and endangered green turtles (Chelonia mydas) are unique because as juveniles they recruit from pelagic to near-shore waters and shift from an omnivorous to primarily herbivorous diet (i.e. seagrass and algae). Nevertheless, when injured and ill animals are admitted to rehabilitation, animal protein (e.g. seafood) is often offered to combat poor appetite and emaciation. We examined how the fecal microbiome of juvenile green turtles changed in response to a dietary shift during rehabilitation. We collected fecal samples from January 2014 -January 2016 from turtles (N = 17) in rehabilitation at the Georgia Sea Turtle Center and used next generation sequencing to analyze bacterial community composition. Samples were collected at admission, mid-rehabilitation, and recovery, which entailed a shift from a mixed seafood-vegetable diet at admission to a primarily herbivorous diet at recovery. The dominant phyla changed over time, from primarily Firmicutes (55.0%) with less Bacteroidetes (11.4%) at admission, to primarily Bacteroidetes (38.4%) and less Firmicutes (31.8%) at recovery. While the microbiome likely shifts with the changing health status of individuals, this consistent inversion of Bacteroidetes and Firmicutes among individuals likely reflects the increased need for protein digestion, for which Bacteroidetes are important. Firmicutes are significant in metabolizing plant polysaccharides; thus, fewer Firmicutes may result in underutilization of wild diet items in released individuals. This study demonstrates the importance of transitioning rehabilitating green turtles to an herbivorous diet as soon as possible to afford them the best probability of survival.
 ...
PMID:The effect of diet on the gastrointestinal microbiome of juvenile rehabilitating green turtles (Chelonia mydas). 3194 Mar 80