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Query: UMLS:C0013911 (emaciation)
 1,059 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A child, aged 6 years 3 months, with a triglyceride storage disorder in peripheral adipose tissue, microcephaly, and gross emaciation has been studied at autopsy. The mean triglyceride content of adipocytes in hand and foot was 0.17 +/- 0.02 mug/cell and 0.18 +/- 0.02 mug/cell. Adipocytes from abdominal tissue were small, irregular, and difficult to measure accurately, reflecting the degree of cachexia. Basal tissue contents of cyclic AMP and release of glycerol and fatty acid from peripheral tissue of the child were in the same range as adult tissues. None of these measurements, however, were increased by incubation with isoprenaline (10(-5 M), compared to a three- to seven-fold increment in adult subcutaneous tissues and to a four- to ten-fold increment of glycerol and cyclic AMP in peripheral adipose tissue of a control child aged 10 years. We postulate that the proband may have had a defect of adenyl cyclase or catecholamine receptor, which has a role in the abnormal storage of triglyceride in peripheral adipose tissue.
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PMID:Triglyceride storage disease: a defect in activation of lipolysis in adipose tissue. 84 May 64

Rectal stricture occurred in each of 23 pigs submitted for necropsy from eight Indiana farms. Each stricture was an annular cicatrization of the rectal wall, 2.0-5.0 cm anterior to the anorectal junction. Emaciation, colonic dilatation and compression atrophy of abdominal and thoracic viscera were a result of chronic obstipation and inanition. Most pigs with strictures had severe enteric disease 4-8 weeks before the strictures occurred. Salmonella typhimurium was isolated from seven of the eight groups of pigs examined. Ulcerative proctitis, a possible precursor of rectal stricture, was frequently in pigs with enterocolitis caused by S. typhimurium.
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PMID:The pathogenesis of porcine rectal stricture. I. The naturally occurring disease and its association with salmonellosis. 85 Sep 93

The paper is concerned with a description of a special form of nervous anorexia related to the presence of vomitophobia. The disease appears on the background of a somatogenic asthenia as a psychogenic reaction and leads to an expressed vomiting reaction. The vomiting reaction becomes fixated with a habitual form of reaction and eventually leads to an emaciation and a development of a special vomitophobic syndrome (vomitophobia proper, voluantary and involuntary vomiting, limitation in food as a measure against vomiting, depression, special ideas of reference).
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PMID:[Atyptical forms of anorexia nervosa]. 85 42

Although the figure of unreported cases of neglected children is much higher than that of physical ill-treatment of children, neglect has rarely received attention, in most cases only when traces of physical ill-treatment were proven at the same time. Symptomatic are in the first place intense emaciation as well as dry puckered, scaly and extremely dirty skin, lack of subcutaneous fatty tissue and of Bichat's fat pad, matted hair, aged face, sunken eyes, and eczema from urine with ulcerations in the buttock and thigh regions. In addition one finds signs of localized hypothermia or rickets. My own observations cover 54 cases in which neglect and malnutrition have caused the death of the children involved. All the children had been living in extremely bad social conditions. The backgrounds of the children's mothers were also socially poor. Most of the mothers were too young to fulfill their duties. The fathers, where known, were alcoholics, unwilling to work and seldom cared for their family. They too were often too young to cope with their role as father. In this day and age, which has provided us with a much better understanding of the importance of the early development of the child for its later social attitude, mothers with all their problems and difficulties should not be left on their own. Motherlike behaviour is not necessarily programmed with the birth of a child. Mother duties must be learned as early as possible. This process should begin during pregnancy at the latest. A few proposals will be made.
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PMID:The death of children following negligence: social aspects. 85 87

Infection of pigs by the whipworm (Trichuris suis) resulted in profuse diarrhea on postinfection days 17 to 21. Anorexia, retardation of growth, dehydration, and emaciation were observed in infected pigs. Scanning electron micrography showed nematodes embedded in the mucosa of the cecum and colon, with resultant disruption of the mucosa. Infected pigs had decreased values of albumin, amylase, calcium and creatine phosphokinase, but increased values of alpha-, beta-, and gamma- globulins, total iron-binding capacity, copper, potassium, uric acid, and aspartate aminotransferase.
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PMID:Pathophysiology of swine trichuriasis. 88 15

Donkeys experimentally infected with Trypanosoma brucei showed dullness, weakness, fever, inappetence, conjunctivitis, tachycardia and polydyspnoea soon after detectable parasitaemia. The parasitaemia was generally low with transient high peaks except in the terminal stage when there was sustained high parasitaemia. A moderate anaemia was present as from the second week of infection but it was not progressive. There was a marked leucopoenia within 24 h of patent parasitaemia. Death occurred 2 to 2 1/2 months after infection and at necropsy there was severe emaciation as well as mild serous effusion. Histologically, there was a nonsuppurative encephalomyelitis, cranial neuritis, extensive haemosiderosis, hyperplasia of follicles in lymph nodes and spleen and giant cell reaction in lymph nodes. Trypanosomes were present in the cerebrospinal fluid, the eye and serous effusions. These observations are similar to those previously reported in other animals infected with T. brucei.
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PMID:Clinical, haematological and pathological studies in donkeys experimentally infected with Trypanosoma brucei. 90 95

A case of transitional cell carcinoma of the prostatic and anterior pelvic urethra of a cat is presented. Primary urinarty tract neoplasms in the cat are rare, and transitional cell carcinoma with major involvement of the urethra has not been previously reported. The appearance and location of this tumor made differentiation from a prostatic carcinoma difficult. The clinical presentation consisted of emaciation, constipation, anorexia, and hematuria.
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PMID:Transitional cell carcinoma of the urethra in a cat. 94 76

Simultaneous parenteral vaccination against typhoid and cholera lead to death through either anaphylactic shock or endotoxic shock in a 36-year-old male. At autopsy the charactertic features of shock as well as chronic interstitial myocarditis were noted. Moreover, fresh histiocytic and lymphocytic nodules were found in the liver, heart and meninges. A review of the literature dealing with lethal complications following parenteral tyhoid vaccinations shows an increased risk in debilitated persons (emaciation, stress, cold). Most of the fatalities occurred in persons who had previous disturbances of the cardiovascular system, as in the case reviewed here. Cardiac failure, Landry's paralysis, renal failure and disturbances of skin, joints and intestines may also follow typhoid vaccinations. However, these latter complications are usually not lethal. The patients presented here had many of the conditions which are known to aggravate the situation and to lead to a lethal culmination. The review of this case and the disucussion following it shows that only healthy persons should receive the parenteral typhoid vaccination. Hopefully, the presentation of this material will help prevent fatalities of this type in the future.
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PMID:Lethal complications of typhoid-cholera-vaccination. (Case report and review of the literature). 98 98

Acute and chronic forms of disease can be distinguished in Trypanosoma vivax infection in the goat. The main difference between the acute and chronic form seems to be the presence of microthrombi in the acute stage of infection; these consist of platelets, trypanosomes, monocytoid cells and some fibrin. This thrombus formation seems directly related to the high parasitaemia in acute trypanosomiasis and may result in ischaemia which could also explain the haemorrhages, the oedema of the lungs and other tissues, and the necrotic changes found in several organs. The anaemia, associated with erythrophagocytosis, haemosiderosis, extramedullary haemopoiesis and hyperactivity of the bone marrow, seemed to be of haemolytic origin. The factors leading to emaciation seemed to be degenerative atrophy of muscular tissue and loss of protein in the urine caused by a possible immune complex glomerulonephritis.
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PMID:The pathology and pathogenesis of Trypanosoma vivax infection in the goat. 102 33

When deaths and symptoms of chronic emaciation not due to any apparent cause occurred in weaned lambs, the morphological changes observed suggested that the liver probably was the main organ, the function of which was impaired. This was believed to be so because of the homogenity of the changes in this organ and the disseminated character of the lesions of the liver. These were termed chronic as secondary perilobular reactions occurred in addition to primary degenerative changes of the parenchyma, in which septa appeared in addition to lymphocytic infiltration in the portal triad. In view of the epidemiological findings, this heaptitis was believed to be infectious rather than toxic.
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PMID:[Chronic hepatitis in lambs (author's transl)]. 115 52


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