Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013911 (emaciation)
 1,059 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mice with the Otx2+/- mutation often die during the postneonatal period. Before death these animals, generated from TT2 ES cells and crossed with CBA mice, develop a dome-shaped head, weakness of the limbs, kyphosis, lethargy, drowsiness, and emaciation. Autopsy of these mice revealed eminent dilatation of lateral ventricles and a ballooned cerebrum. Histological analysis shows edematous change of the periventricular white matter. These results suggest that Otx2 functions as a head organizer, and a mutation of this gene is a likely cause of hydrocephalus in mammals. Additionally, craniobasal skeletal anomaly in half of the heterozygotes and dwarfism in some of the female heterozygotes are described.
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PMID:Hydrocephalus in the Otx2+/- mutant mouse. 939 63

We report a rare case of pilocytic astrocytoma and diencephalic syndrome occurring together in a 30-year-old woman with neurofibromatosis type 1 (NF-1). Diencephalic syndrome included emaciation and somnolence. Gadolinium-enhanced magnetic resonance imaging revealed a brain tumor in the optic chiasmal-hypothalamic region, which invaded the thalamus, brain stem and cerebellum. A biopsy specimen from the chiasmal tumor was compatible with pilocytic astrocytoma. Although she received radiation therapy, she died 22 months after the onset of the disease.
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PMID:[Pilocytic astrocytoma and diencephalic syndrome in an adult with neurofibromatosis type 1]. 1450 50

We report a case of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) with accompanying severe strongyloidiasis in a 52-year-old male. On admission, he showed drowsiness and emaciation with severe hyponatremia. We gave sodium (saline or salts) in an i.v. drip infusion and orally without improvement. A urinalysis and plasma osmotic pressure test indicated SIADH, therefore, treatment was changed to restrict his sodium intake. The hyponatremia gradually improved initially, but the appetite loss, nausea, and hyponatremia continued. Endoscopy revealed white patches on the stomach wall and histopathological examination revealed infestation of the mucosal epithelium with numerous Strongyloides stercoralis larvae. Ivermectin treatment was then initiated and the abdominal symptoms and hyponatremia gradually resolved. We carefully investigated the underlying cause of the SIADH, such as disease of the central nervous system, lung cancer, and other malignancies, but no abnormality or clear cause could be found. We concluded that the patient developed SIADH secondary to severe S. stercoralis infection.
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PMID:Syndrome of inappropriate secretion of antidiuretic hormone associated with strongyloidiasis. 1753 72

Outbreaks of clinical reticuloendotheliosis (RE) were observed in a turkey flock and two pullet flocks. Clinical signs in turkeys included sleepiness, weakness, anorexia, diarrhoea and reduced egg production. The pullets showed severe emaciation, loss of back feathers, anorexia and diarrhoea. Fifteen out of 54 turkeys died before the flock was killed. One pullet flock suffered 20% mortality while the other had an average daily mortality of four to six out of 2000 birds for 9 weeks with a total mortality of 16.4%. Necropsy of the dead turkeys and pullets showed neoplastic nodules or grey foci in the internal organs especially the liver, intestines and spleen. Histopathological sections of the organs had proliferation of reticular cells with necrosis of the parenchyma and focal lymphocytic infiltration. RE virus antigens and precipitating antibodies were detected in the serum samples collected from the birds. It was suspected that natural RE could be a more serious problem than earlier reported in some countries.
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PMID:Naturally occurring clinical reticuloendotheliosis in turkeys and chickens. 1867 Oct 14