Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013911 (emaciation)
 1,059 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 4-year-old stallion was examined because of a 2-month history of inappetance and weight loss. Diarrhoea had also developed a month before presentation. Abnormal clinical findings were emaciation, diarrhoea, ventral oedema, palpable mesenteric lymph node enlargement and a large mass in the left cranial portion of the abdomen. Significant laboratory findings were anaemia (packed cell volume 0.21 litres/litre), hypoalbuminaemia (16 g/litre) and xylose malabsorption. The horse was euthanased and at necropsy a 10.5 kg pendunculated mass composed of granulation tissue was found within and attached to the stomach. There was villous atrophy diffusely throughout the small intestine. The inciting cause of the gastric mass was not determined.
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PMID:Exuberant granulation tissue in the stomach of a horse. 694 86

In a sheep which was euthanased because of severe emaciation and weakness, slight thickening of the ileum was seen grossly. Microscopically there was a granulomatous ileitis with obliterative lymphangitis and lymphangiectasis. Granulomatous lesions were also present in the liver and some mesenteric lymph nodes. Large numbers of acid-fast bacilli were present within epithelioid macrophages in the lamina propria of the ileum. Although the identity of the Mycobacterium spp. involved was not established, the possibility of paratuberculosis is discussed. The apparent rarity of this disease in sheep in South Africa is considered. Particular attention is drawn to the absence of diarrhoea in this case, to the slightness of the gross changes and to the importance of submitting material for mycobacterial culture.
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PMID:A mycobacteriosis in a sheep resembling paratuberculosis (Johne's disease). 727 75

A 63 year-old woman with a malignant duodenocolic fistula of colonic origin was so diagnosed following radiological examination. She had symptoms of feculant vomitus, persistent diarrhea and emaciation. Following preoperative treatment of the nutritional and electrolyte disorders with intravenous hyperalimentation, a one-staged right hemicolectomy and pancreatoduodenectomy was performed successfully. We emphasized that an en-bloc removal of all the possibly involved structures is the most successful procedure for malignant duodenocolic fistula of colonic origin.
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PMID:Malignant duodenocolic fistula--a case report. 731 Nov 89

Of 109 dogs submitted with complications following ovariohysterectomy, twenty were found to show enterological problems. Presenting symptoms in these animals consisted in vomiting, diarrhoea and emaciation. A large number of animals also showed body temperatures above 39 degrees C. An irregular, often painful mass was palpable on examination of the mesogastrium in seventeen cases. Plain radiography revealed the features of ileus in ten dogs, a mass of soft tissues in the abdominal cavity in six and the pattern of peritonitis in five cases (two animals were classifiable with two groups). One dog did not show any changes. Laparotomy was performed in all twenty dogs. In view of the extent of the lesions, euthanasia was performed in ten animals. Partial enterectomy was performed in the other ten; some of these dogs are still alive at the time of writing. The findings at laparotomy and subsequent post-mortem examination, if any, may be summarized as follows: - there were adhesions between the ovarian-stump granulomas and an intestinal loop in five animals; - twelve animals showed adhesions between the ovarian-stump granuloma and the intestines which also adhered to each other; in five of these bitches, the intestinal loops were also attached to the wall of the abdomen, and also to the cervix stump in two cases; - three dogs only showed adhesions between intestinal loops; the cervix stump was involved in the adhesions in one dog.
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PMID:[Enterological complications following ovariohysterectomy in dogs (author's transl)]. 732 17

Phentyrin toxicity depends to a large measure on the route of its administration. Adequately toxic doses of phentyrin intravenously are approximately ten times as less compared to peroral administration. High doses of the drug produce appetite loss, occasional vomiting, salivation, diarrhea, flabbiness and weight loss. ECG shows slow pulse, reduced voltage and changes in T wave. At early periods the animals' death ensues with phenomena of emaciation, a delayed death can be recorded only in some cases. Morbid anatomy shows atrophic changes in the lymphatic nodes, in the spleen, thyroid, in the gastrointestinal mucosa, and changes in the liver and kidneys. Phentyrin in tolerated doses exerts no adverse action on stem cells of bone marrow, but affects spleen cells. The drug alters the weight of some endocrine organs -- the thyroid, uterus and adrenals.
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PMID:[Toxicological properties of fentirin]. 737 84

Five mule deer fawns (Odocoileus hemionus) ranging in age from 3 to 6 weeks were given sporulated Eimeria mccordocki oocysts orally. Four of the five fawns developed coccidiosis. Initial clinical signs appeared by 8 to 9 days postinoculation and included elevated body temperature and bloody diarrhea. Dehydration and limited emaciation occurred as the disease progressed. The disease was allowed to run its course in one fawn and oocysts were passed in the feces on the 16th day following inoculation. Oocysts passage continued until the 27th day, at which time the animal appeared to be completely recovered. The remaining animals demonstrated all signs of coccidiosis and were euthanized prior to passing oocysts. Intracellular stages of E. mccordocki in these animals were confined to the last 75 to 100 cm of the ileum. The cytoplasm of each infected epithelial cell contained one to five meronts. The intestinal epithelium was inflammatory and contained many necrotic foci.
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PMID:Experimental coccidiosis in mule deer fawns. 746 11

Cadmium (Cd) loading trials were conducted on a total of 110 (3 x 10 and 4 x 20) broiler chickens prereared for 21 days. The control chickens received no cadmium, while chickens in the six treatment groups were given different doses of Cd as an aqueous solution of CdSO4 administered either into the crop or mixed in the feed. The chickens were kept in a climatized animal house and treated usually for 3-5 weeks (maximum 68 days), with the exception of group Cd-75 chickens which were treated up to 239 days of age. The chickens' health status, body mass and feed consumption were monitored throughout the trial. On days 14-20 and on day 42 of the trial 2 chickens per group, then at the end of trial a total of 25 chickens were killed in anaesthesia. These birds, together with chickens that died or were killed during the trial, were subjected to detailed gross pathological examination. From 11 organs (kidney, liver, spleen, testicle, brain, myocardium, skeletal muscle, lungs, digestive tract, pancreas, tubular bones) of these chickens samples were taken for assay for a total of 16 elements, as well as for light and electron microscopic examination. With the exception of groups Cd-30 and Cd-600, no abnormal clinical signs were observed in the first two weeks of the trial. Chickens of group Cd-30 died before day 8-12 of the trial among signs of complete anorexia, rapid emaciation, huddling and diarrhoea, while chickens of group Cd-600 died before day 28, showing similar clinical signs. The body mass of chickens fed a Cd-supplemented diet either remained constant or decreased substantially, in a degree proportional to the Cd load. The only exception was group Cd-2.5, in which the average body mass of birds at the end of week 8 slightly exceeded that of the controls. Four out of the 10 cockerel chicks fed a diet containing 75 ppm Cd up to 239 days of age died of intercurrent diseases; the remaining six grew well and reached a body mass of 3.8-4.3 kg. Feed conversion efficiency was satisfactory in the control group and in group Cd-2.5 (2.1 and 2.4 kg, respectively) and could not be evaluated in a realistic manner in the other groups. At necropsy, the cockerel chicks of groups Cd-30 and Cd-600 showed severe emaciation, liver and kidney degeneration, myocardial hypertrophy and cardiac dilatation.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Complex study of the physiological role of cadmium. III. Cadmium loading trials on broiler chickens. 749 61

An epidemiological investigation into an "illthrift" problem occurring on a dairy farm adjacent to an alloy-processing unit, established that the probable cause of the problem was chronic vanadium poisoning. The disease manifested initially in animals 4-18 months old which showed emaciation, chronic diarrhoea and, in some cases, rhinitis, conjunctivitis and recumbency followed by death. Post-mortem (n = 17) and clinical-pathology findings (n = 60) indicated that malabsorption and immunosuppression were the basis of the pathogenesis in affected animals. Eight months after the commencement of the investigation, adult cows began showing evidence of emaciation, reduced milk production and an apparent increase in the number of abortions, stillbirths and dystocias. Over a 2-year period, 134 surface-soil samples, 134 subsoil samples and 134 grass samples from the farm were analysed for various fractions of vanadium. Thirty-four of each of these samples were collected at different time intervals (autumn 1990, summer 1991 and winter 1991) and at varying distances and directions from the processing unit, in order to gauge the magnitude of the problem, and the distribution pattern of vanadium, and to identify possible seasonal trends. The remaining 100 of each of these samples were taken at 100-m intervals over an area of approximately 1,140,000 m2 directly adjacent to the processing unit so that concentration isolines for vanadium could be drawn and the source more conclusively identified. The levels of vanadium were found to be highest closest to the mine, and surface-soil levels were consistently higher than subsoil levels, suggesting aerial pollution, which was confirmed by air sampling.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Vanadium air pollution: a cause of malabsorption and immunosuppression in cattle. 750 62

Recently we encountered a case of pulmonary tuberculosis with HIV infection. The patient was 54-years old male. His chief complaints were anemia, emaciation and severe diarrhea. He was admitted to our hospital on September 18, 1992. He had been diagnosed in another clinic as having pulmonary tuberculosis before the admission to our hospital. His chest films taken on admission revealed homogeneous infiltrates with cavitation in right upper lobe. Serial chest X-rays consisted with the findings of post-primary tuberculosis. Sputum smear for acid fast bacilli was positive. From his clinical manifestations and life-history, we had a suspicion that he had infected with HIV. Laboratory findings were as follows: serum albumin level was 1.9 g/dl, CRP was 10.2 mg/dl, serological tests for HIV were positive by EIA, IFA and western blott method, total lymphocyte count was 819/microliters, CD4+ T lymphocyte count was 120/microliter CD4+/CD8+ ratio was 0.2. He was treated with AZT, isoniazid, streptomycin and rifampicin. The disease progressed rapidly and interstitial pneumonia, jaundice and clouding of consciousness appeared at the terminal stage. He expired on October 14, 1992. In this paper, the authors reported a case of pulmonary tuberculosis with HIV infection and also reviewed 5 cases of pulmonary tuberculosis associated with HIV in Japan.
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PMID:[A case of pulmonary tuberculosis with HIV infection--review of 5 cases in Japan]. 783 23

Serious incidents of pyrrolizidine alkaloidosis of cattle in 10 herds exposed to the Australian native plant, Senecio lautus (Asteraceae), were seen in central Queensland during 1988-1992. The deaths of 226 cattle were recorded. A mean of 8% of cattle died in affected groups (range 2 to 58%). Sickness and deaths usually occurred some months after access to S lautus. Typically, affected cattle lost body condition to the point of emaciation before dying and had persistent diarrhoea. Some animals developed abnormal behaviour and died after a shorter illness. Liver specimens from affected cattle in all herds contained lesions consistent with pyrrolizidine alkaloidosis. Thin layer chromatography of extracts of blood and liver samples from cattle from 5 herds detected pyrrolic metabolites. The identity of these was confirmed by mass spectroscopy on samples from one herd. Unseasonal autumn and winter rain after a dry summer appeared to favour growth of S lautus at the expense of other pasture species. A subsequent dry period promoted consumption of S lautus and was followed by a cluster of poisoning incidents.
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PMID:Pyrrolizidine alkaloidosis of cattle associated with Senecio lautus. 794 96


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