Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013911 (emaciation)
 1,059 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of 109 dogs submitted with complications following ovariohysterectomy, twenty were found to show enterological problems. Presenting symptoms in these animals consisted in vomiting, diarrhoea and emaciation. A large number of animals also showed body temperatures above 39 degrees C. An irregular, often painful mass was palpable on examination of the mesogastrium in seventeen cases. Plain radiography revealed the features of ileus in ten dogs, a mass of soft tissues in the abdominal cavity in six and the pattern of peritonitis in five cases (two animals were classifiable with two groups). One dog did not show any changes. Laparotomy was performed in all twenty dogs. In view of the extent of the lesions, euthanasia was performed in ten animals. Partial enterectomy was performed in the other ten; some of these dogs are still alive at the time of writing. The findings at laparotomy and subsequent post-mortem examination, if any, may be summarized as follows: - there were adhesions between the ovarian-stump granulomas and an intestinal loop in five animals; - twelve animals showed adhesions between the ovarian-stump granuloma and the intestines which also adhered to each other; in five of these bitches, the intestinal loops were also attached to the wall of the abdomen, and also to the cervix stump in two cases; - three dogs only showed adhesions between intestinal loops; the cervix stump was involved in the adhesions in one dog.
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PMID:[Enterological complications following ovariohysterectomy in dogs (author's transl)]. 732 17

We describe a case of sudden death caused by a rare complication of Crohn's disease. A 29-year-old man with Crohn's disease who had not taken medications regularly complained of nausea, vomiting, and abdominal pain for 2 days, and then died suddenly. Autopsy revealed protruding intestinal loops filled with gas, internal fistulas between fused loops of the terminal ileum, and complete obstruction of the fistulous tract. The histologic findings of transmural inflammation consisting of lymphocytic infiltration, accumulation of partially hyalinized collagen, and fibrosis in the skip areas from the ileum to the cecum were compatible with Crohn's disease. Furthermore, marked emaciation, atrophic change of the heart muscle, and diffuse fatty change of the liver were found. Although the patient died of obstructive ileus caused by a stricture produced by progression of Crohn's disease, he was severely affected by malnutrition which may have been fatal. This case not only illustrates that Crohn's disease can cause obstructive ileus and sudden death, but also makes the forensic pathologist realize the importance of suspecting the presence of an active inflammatory bowel disease in a patient with internal fistulas or malnutrition.
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PMID:Sudden death of a patient with Crohn's disease. 978 Jun 67

A 48-year-old man was referred to our hospital in December, 2005 because of general fatigue, gait disturbance and bradycardia. He had a history of polysurgery due to recurrent ileus and had been treated with home total parenteral nutrition for the short-bowel syndrome since 2003. Clinical findings on admission included marked emaciation and severe weakness of the extremities. Pancytopenia was noted in the peripheral blood. The serum levels of copper and ceruloplasmin were 3 microg/dl and 3 mg/dl, respectively, while Vit. B12 and folate were within the normal range. The bone marrow demonstrated cytoplasmic vacuolation in the myeloid and megakaryocytic series, and sideroblastic changes. No evidence of hematologic malignancies was presented. The diagnosis was copper deficiency and the patient was treated with copper supplementation. Four weeks after copper therapy, the serum level of copper rose to 50 microg/dl and ceruloplasmin to 14 mg/dl. Significant improvements in the hematologic profile, ECG findings and weakness of extremities were noted. Although bicytopenia (anemia and neutropenia) is considered to be a feature of hematologic disorders caused by copper deficiency, the present case showed pancytopenia. The exact mechanism of the unusual association of thrombocytopenia and other abnormalities with copper deficiency remains to be elucidated.
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PMID:[Copper deficiency with pancytopenia, bradycardia and neurologic symptoms]. 1744 78