Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013911 (emaciation)
 1,059 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Feline leukemia virus (FeLV) infection was diagnosed immunohistologically on paraffin-embedded tissues obtained from 1,095 necropsied cats. Significant association of FeLV infection was demonstrated by chi 2 and Fisher's tests with various conditions and diseases (ie, anemia, tumors of the leukemia/lymphoma complex, feline infectious peritonitis, bacterial infections, emaciation, FeLV-associated enteritis, lymphatic hyperplasia, and hemorrhage). Unexpected findings associated with FeLV infection were icterus, several types of hepatitis, and liver degeneration. A negative association with FeLV infection was found for most parasitic and viral infections, including feline panleukopenia. Neither positive nor negative associations were established for FeLV infection and most forms of nephritis, including severe glomerulonephritis. Feline leukemia virus-infected cats were significantly (Kruskal-Wallis test) older than were FeLV-negative cats with the same nonneoplastic FeLV-associated diseases.
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PMID:Frequency and significance of feline leukemia virus infection in necropsied cats. 303 51

The historic, physical, laboratory, and histologic findings for 74 cats with chronic renal disease were reviewed. Most cats were older, and no breed or sex predilection was detected. This most common clinical signs detected by owners were lethargy, anorexia, and weight loss. Dehydration and emaciation were common physical examination findings. Common laboratory findings were nonregenerative anemia, lymphopenia, azotemia, hypercholesterolemia, metabolic acidosis, hyperphosphatemia, and isosthenuria. The most common morphologic diagnosis was chronic tubulointerstitial nephritis of unknown cause. The other pathologic diagnoses were renal lymphosarcoma, renal amyloidosis, chronic pyelonephritis, chronic glomerulonephritis, polycystic renal disease, and pyogranulomatous nephritis secondary to feline infectious peritonitis.
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PMID:Clinicopathologic findings associated with chronic renal disease in cats: 74 cases (1973-1984). 358 99

A 12-year-old girl, who had been diagnosed as having Cockayne syndrome (CS), was admitted for emaciation and dehydration. On admission the patient had mild chronic renal failure (glomerular filtration rate: GFR 50 mL/min) and hyperuricemia. After rehydration, allopurinol was commenced for her hyperuricemia. Then, her renal function rapidly deteriorated (GFR 20 mL/min) with enhancement of proximal tubular dysfunction and hypertension. A renal biopsy showed that the patient had acute tubulointerstitial nephritis (ATIN). Based on this diagnosis, allopurinol was stopped and prednisolone was started (2 mg/kg per day), following which the renal tubular function improved. However, the proteinuria intensified to become nephrotic syndrome. After 1 month the patient developed a gastric ulcer. Famotidine was commenced but GFR deteriorated and renal proximal tubular dysfunction re-occurred. The renal pathology was evaluated by referring to the previous reports of renal pathology in CS. It is suggested that rapid deterioration of the renal function in CS patients might be the result of ATIN. In addition, the present nephrotic syndrome seemed to be accompanied by ATIN, as in other reports.
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PMID:Cockayne syndrome with recurrent acute tubulointerstitial nephritis. 1704 Feb 91

1. In work along this line it is most important to have a simple method of determining the catalytic activity of tissues. The method must be such that several observations can be made during a single experiment, so that a better idea can be obtained of the velocity of the reaction at various intervals. 2. The catalytic activity of human tissues varies greatly in diseases. A. Nephritis.-The kidney always shows the most marked reduction although the other tissues examined, blood, lung, liver, spleen, likewise show decrease in their power of decomposing hydrogen peroxide. This reduction varies directly with the severity of the pathological lesion in the kidney and the clinical symptoms. The urine also in cases of nephritis shows a much greater inhibiting power than normal urine. This may be accounted for by the reaction of the urine, and subsequent work must prove whether or not the kidney takes any more active part in nephritis and secretes into the blood and urine a substance which manifests itself by a reduction in the catalytic activity. B. The catalytic activity of the blood in the two cases of eclampsia which we have studied was not reduced. This is the most important fact we have so far obtained, if it can be substantiated, since it can furnish us with a ready ante-mortem means of differentiating eclampsia and nephritis. C.Pneumonia.-The lung in the stage of red hepatization has an increased catalytic activity. This increase varies directly with the number of intact red blood cells in the exudate, and in the engorged capillaries. Strength is given to this conclusion by the fact, that on the one hand, there is no increased activity in gray hepatization, while on the other hand, there is an enormously increased activity in the fresh hemorrhagic infarct. D. Tuberculosis.-The decreased activity of the lung in tuberculosis is probably due, for the most part, to the lack of blood in the diseased area, while the lowered activity which is present in the other organs is to be explained by the anaemia and emaciation which accompanies the process. Whether there is a specific catalytic inhibiting substance generated by the process, has not been determined. E. There was no reduction of the catalytic activity in the cases of diabetes mellitus and jaundice studied. F. In the one case of asphyxiation by illuminating gas, there was decided decrease in the catalytic activity of the blood. G. The tissues in the one case of congenital syphilis showed a marked lowering of the catalytic activity. 3. There is a slight decrease in the catalytic activity of the tissues due to post-mortem change, but this is so slight that it is hardly to be taken into consideration in the interpretation of the results obtained. 4. There is no marked change in the catalytic activity due to age. In concluding, we wish to thank Dr. A. S. Loevenhart, at whose suggestion this enzyme was studied, for the unfailing interest with which he has followed the progress of this work, and for the many valuable suggestions he has given us.
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PMID:ON THE OCCURRENCE OF CATALASE IN HUMAN TISSUES AND ITS VARIATIONS IN DISEASES. 1986 62

The acute exudative glomerular lesion of the rabbit's kidney caused by crotalus venom does not lead to a subacute or chronic glomerulonephritis. The hemorrhagic lesion of the glomerular tuft may show a process of repair characterized by the ingrowth, into the hemorrhagic masses, of endothelial cells from the uninjured part of the tuft. This process is, however, more analogous to the organization of a red thrombus than it is to any form of glomerular lesion known in man, and can hardly serve as an experimental demonstration of the mode of development of a subacute or chronic glomerular nephritis. On the other hand, crotalus venom causes a persistent albuminuria and extensive tubular degeneration and cast formation, with death, preceded by great emaciation, after five to six weeks.
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PMID:AN EXPERIMENTAL STUDY OF THE LATE GLOMERULAR LESIONS CAUSED BY CROTALUS VENOM. 1986 91

One hundred and twenty stranding events of Stejneger's beaked whales were reported in Japan between 1999 and 2011. The purpose of this study is to introduce pathological data and to discuss probable causes of death for 44 Stejneger's beaked whales among them. The significant pathological findings were the pulmonary edema, parasitic granulomatous nephritis, emaciation, amyloidosis, suppurative bronchopneumonia and so on. The probable causes of death were categorized as noninfectious in 43 of the cases, which included drowning, starvation and secondary amyloidosis. One individual was diagnosed with septicemia, which was the only example of an infectious disease. Because we could not always perform advanced analyses, such as microbiology tests, biotoxin examinations or contaminant analyses, the finality of our findings may be impaired. However, the present study has broad implications on the causes of death of Stejneger's beaked whales of the seas around Japan, which are valuable for the future studies and for the detection of emerging diseases.
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PMID:Pathological findings and probable causes of the death of Stejneger's beaked whales (Mesoplodon stejnegeri) stranded in Japan from 1999 and 2011. 2532 4

IgG4-related disease (IgG4RD) is a recent inflammatory process of supposed autoimmune etiology, which is characterized by elevated serum IgG4 levels, dense lymphoplasmacytic infiltration rich in IgG4-positive plasma cells and storiform fibrosis. Tubulointerstitial nephritis is the most common renal manifestation, with different degrees of kidney dysfunction and variable clinical findings. Herein, the authors describe a new case of IgG4 tubulointerstitial nephritis (IgG4TN), and discuss clinic and pathologic criteria. Male patient, 72 years-old, was admitted on hospital service with clinical complaint of asthenia, loss of strength, emaciation, and anosmia. Previous history included type 2 diabetes mellitus. Laboratorial data included normochromic anemia, proteinuria, and creatinine elevation. Bilateral kidney ultrassonography/computed tomography revealed a heterogenous parenchyma, with diffuse irregular dense zones, areas of fibrosis on upper poles, and hydronephrosys. Kidney biopsy showed a dense interstitial lymphoplasmacytic infiltrate, with more than 50 plasma cell per high power field, irregular areas of fibroblastic and collagenous fibrosis, focal tubulitis, and normal glomeruli. Immunofluorescence revealed mild granular deposition of C3c and IgG in the tubular basement membrane. Immunohistochemestry was positive for CD138, lambda and Kappa light chains, and IgG4 (around forty five IgG4 positive plasma cells per high power field). IgG4 serum level was increased. The diagnosis of IgG4TN was then established. The patient received corticotherapy and strict control of glycemia with insulin, with marked improvement of symptoms and creatinine levels.
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PMID:A brief contextualization on IgG4 tubulointerstitial nephritis based on a case report in south Brazil. 2743 82

A 2-year-female arctic fox (Vulpes lagopus) developed anorexia, dehydration, and emaciation during the quarantine period for importation from Norway, and died 17 days later. At necropsy, a fistula was observed on the left gluteal region, and the left eye, left brain, and kidneys were discolored. Histologically, severe diffuse suppurative meningoencephalitis and renal abscesses were detected. Numerous Gram-positive cocci were detected in these lesions. Multidrug-susceptible Staphylococcus pseudintermedius were isolated from the lesions. These results suggest that S. pseudintermedius can cause severe multifocal suppurative meningoencephalitis and nephritis in foxes. This is the first report of multidrug-susceptible S. pseudintermedius meningoencephalitis and nephritis in a fox.
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PMID:Systemic Staphylococcus pseudintermedius infection in an arctic fox (Vulpes lagopus) with severe multifocal suppurative meningoencephalitis and nephritis. 2988 79