Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013911 (emaciation)
 1,059 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a sheep which was euthanased because of severe emaciation and weakness, slight thickening of the ileum was seen grossly. Microscopically there was a granulomatous ileitis with obliterative lymphangitis and lymphangiectasis. Granulomatous lesions were also present in the liver and some mesenteric lymph nodes. Large numbers of acid-fast bacilli were present within epithelioid macrophages in the lamina propria of the ileum. Although the identity of the Mycobacterium spp. involved was not established, the possibility of paratuberculosis is discussed. The apparent rarity of this disease in sheep in South Africa is considered. Particular attention is drawn to the absence of diarrhoea in this case, to the slightness of the gross changes and to the importance of submitting material for mycobacterial culture.
 ...
PMID:A mycobacteriosis in a sheep resembling paratuberculosis (Johne's disease). 727 75

Paratuberculose enteritis is an infectious and contagious chronic disease of the rumiants. It is characterised by periodic diarrhoea and progressive emaciation and loss of condition, intestinal ileitis and oedematous mucosa with cirumvolutions. The disease is caused by Mycobacterium avium subsp. paratuberculosis. Crohn's disease or inflammatory bowel disease has identical characterization with ileitis, colitis with oedematous state and enlarged intestinal mucosa. Iflammatory infiltration of the intestinal mucosa has a transmural character, affecting the submucosa. The similarity between Crohn's disease and Johne's disease is the reason for considering an identical etiology for both diseases, but in the 75 years of the natural history of Crohn's disease it has been impossible to demonstrate this hypothesis. However, actually the predominant idea is that Mycobacterium avium subsp. paratuberculosis is frequently present in patients with Crohn's disease. This has been demonstrated by hemocultures, PCR and in situ hybridization.
 ...
PMID:[Paratuberculose enteritis and Crohn's disease]. 1806 97