Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 536
DYT1 431
MRI 368
Mol 170
She 139
X-linked 139
dopa-responsive dystonia 133
DQ2 121
tyrosine hydroxylase 106
ATPase 88
GABA 84
CSF 81
endoplasmic reticulum 78
axonal 77
ATP1A3 71
THAP1 69
GTP cyclohydrolase I 65
GCH1 64
DBS 64
SGCE 61
epsilon-sarcoglycan 59
Pol 50
pantothenate kinase 49
Hallervorden-Spatz syndrome 48
glutaryl-CoA dehydrogenase 47
GCH 46
dopamine transporter 44
BPA 43
strabismus 42
ATP 40
DYT11 38
GTP 35
DYT3 35
Wilson disease 33
parkin 32
jerky 32
PLA2G6 32
ceruloplasmin 28
PANK2 28
Na+,K+ ATPase 25
TAF1 24
Rett syndrome 24
ubiquitin 24
X-linked recessive 23
GNAL 23
dopamine D2 receptor 23
asymmetrical 22
DDP 22
PRKRA 21
REM 20
HPD 20
olfactory 19
tau protein 19
polypeptide 19
D2 dopamine receptor 18
alpha-synuclein 18
hypoxanthine-guanine phosphoribosyltransferase 18
SLC2A1 18
PINK1 18
NMDA receptor 18
prolactin 18
FDG 18
sepiapterin reductase 17
PARK2 17
sodium channel 17
NPC1 17
substance P 17
amyloid precursor protein 17
KMT2B 17
CIT 17
ANO3 16
SCA3 16
PARKIN 16
huntingtin 16
XDP 16
WDR45 16
STN 16
MR-1 16
CHAC 16
MIM 16
TATA-binding protein 15
calcium channel 15
ARX 15
membrane protein 15
reserved 15
parvalbumin 14
glutamate receptor 14
ferritin 14
Parkin 13
ATP7B 13
PWI 13
AAA 13
Dystonin 13
nitric oxide synthase 12
Gen 12
CIZ1 12
Na(+)/K(+)-ATPase 12
ferritin light chain 12
DRD2 12
SCA1 12
proteasome 12
HLA 12
INAD 12
PRRT2 12
LRRK2 11
fatty acid hydroxylase 11
GABA(A) receptor 11
MECP2 11
ANOVA 11
ART 11
DJ-1 11
5-HT2A 11
DAT 11
ND6 11
GLUT-1 11
RDP 11
SNARE 11
acetylcholinesterase 11
ATM 11
ATP13A2 11
SCH 11
muscarinic receptor 10
brain-derived neurotrophic factor 10
C19orf12 10
creatine kinase 10
calcitonin 10
GLUT1 10
UTR 10
SNAP 10
glucose transporter 10
interferon 10
alternatively spliced 10
SUCLA2 10
glucocerebrosidase 10
ABC 9
TMS 9
PSP 9
pyruvate dehydrogenase 9
CA1 9
A-T 9
synuclein 9
NPC2 9
HTT 9
BPAG1 9
with Parkinsonism 9
dopa decarboxylase 9
SPR 9
SCA2 9
cage 8
5-HT1A 8
LULL1 8
sigma receptor 8
solute carrier 8
PKAN 8
SLC30A10 8
P14 8
D2R 8
beta-endorphin 8
5-hydroxytryptamine 8
torsinB 8
more...
Disease
Parkinson's disease 1074
parkinsonism 1057
movement disorder 926
Dystonia 693
dyskinesia 422
DYT1 396
epilepsy 338
depression 285
torsion dystonia 271
dementia 240
cerebral palsy 231
Huntington's disease 227
tardive dyskinesia 220
dysphagia 176
encephalopathy 173
stroke 172
psychosis 148
choreoathetosis 147
dysphonia 143
apraxia 141
Tourette syndrome 135
schizophrenia 133
cognitive impairment 123
progressive supranuclear palsy 118
Wilson's disease 106
obsessive-compulsive disorder 105
multiple sclerosis 103
developmental delay 102
akinesia 100
mental retardation 98
Meige syndrome 98
mental retardation 94
Alzheimer's disease 93
migraine 87
neurological disease 83
deafness 74
neuropathy 72
encephalitis 70
Hallervorden-Spatz disease 66
Leigh syndrome 65
optic atrophy 64
hypertension 63
chronic pain 58
brain atrophy 57
hallucinations 53
hemiparesis 52
nystagmus 47
peripheral neuropathy 47
strabismus 47
glutaric aciduria 45
cancer 45
major depressive disorder 43
tic 42
fits 42
XDP 41
prolapse 41
abnormal involuntary movements 41
disinhibition 41
camptocormia 40
aphasia 40
myopathy 40
DRD 40
muscular atrophy 39
regional pain syndrome 39
DYT11 38
amyotrophic lateral sclerosis 37
diabetes 37
sleep disorders 37
sensorineural hearing loss 35
spastic paraplegia 35
genetic disorder 35
Writer's cramp 35
autism 35
scoliosis 34
stereotypies 34
Machado-Joseph disease 33
Cerebellum 32
confusion 32
coma 32
blindness 32
NPC 32
tumor 31
bruxism 30
tetraplegia 30
mental illness 30
restless legs syndrome 30
macrocephaly 29
Writer's cramp 29
polyneuropathy 29
Lesch-Nyhan syndrome 29
Rett syndrome 29
RDP 29
ATM 28
rare disease 28
stuttering 27
pseudobulbar palsy 27
Leber's hereditary optic neuropathy 25
atherosclerosis 25
Pisa syndrome 25
Corticobasal degeneration 25
incontinence 24
DDP 24
cirrhosis 23
hyperphenylalaninemia 23
Niemann-Pick 23
gastroesophageal reflux disease 23
Friedreich's ataxia 23
sleep disturbances 23
coronary heart disease 23
GA I 22
Globus 22
anxiety disorders 22
diplopia 22
lactic acidosis 22
delusions 22
Syndrome 21
obesity 21
Dementia with Lewy bodies 21
essential hypertension 21
acanthocytosis 21
pneumonia 21
DYT7 20
Creutzfeldt-Jakob disease 20
suicide 20
mutism 20
myelopathy 19
xerostomia 19
intellectual impairment 19
mania 19
PARK2 19
failure to thrive 18
ischemia 18
liver disease 18
leukodystrophy 18
West 18
metabolic disorder 18
malnutrition 18
respiratory failure 18
cold 18
catalepsy 18
neuroblastoma 17
reflex sympathetic dystrophy 17
Meige 17
bipolar disorder 17
hydrocephalus 17
mitochondrial disease 17
Sydenham's chorea 17
aggression 17
myocardial ischemia 16
Essential tremor 16
conversion reaction 16
temporal lobe epilepsy 16
Spinocerebellar ataxia 16
dysautonomia 16
PDC 15
spastic diplegia 15
radiculopathy 15
hemichorea 15
brain dysfunction 15
sensory neuropathy 15
more...
Symptom
dystonia 8418
tremor 1060
myoclonus 528
pain 498
ataxia 449
chorea 440
spasticity 431
blepharospasm 426
seizures 367
torticollis 285
dysarthria 236
spasm 177
weakness 170
bradykinesia 167
cerebellar ataxia 128
hypotonia 115
headache 107
athetosis 94
Cervical dystonia 78
hypertonia 74
hemiplegia 73
anesthesia 72
agitation 69
Spasmodic Torticollis 67
paresis 56
fatigue 52
sleepiness 51
vomiting 48
ophthalmoplegia 47
insomnia 39
abnormal gait 36
stridor 33
Involuntary Movement 32
Spasmodic dysphonia 31
nausea 28
incoordination 27
clumsiness 26
discomfort 26
dizziness 26
discomfort 26
apathy 21
lethargy 21
neck pain 20
dyspnea 20
vertigo 19
paraparesis 18
muscle rigidity 17
drooling 17
asterixis 17
nausea and vomiting 17
tachypnea 16
myalgia 16
constipation 16
ataxic gait 15
catatonia 15
Extrapyramidal symptoms 15
diarrhea 14
motor symptom 14
intention tremor 14
muscle cramps 14
clonus 14
back pain 12
Acute dystonia 12
hepatosplenomegaly 12
cough 11
low back pain 11
paresthesia 10
blurred vision 9
angina 9
neuralgia 9
respiratory distress 8
tinnitus 8
distraction 8
facial pain 8
pallor 8
aphonia 7
twitching 7
splenomegaly 7
abdominal pain 7
dry eye 7
hypothermia 7
Psychiatric symptoms 7
thinning 7
muscle stiffness 7
analgesia 7
numbness 7
fasciculation 7
Sedation 7
functional recovery 7
stigma 7
memory loss 6
cyanosis 6
asthenia 6
cardialgia 6
syncope 6
collapse 6
Decreased activity 6
Kayser-Fleischer ring 6
pelvic pain 6
ENT 5
Parkinsonian tremor 5
neurological disability 5
hoarseness 5
exhaustion 5
dysesthesia 5
Hemiballism 5
Antecollis 5
Spastic 5
forgetfulness 5
photophobia 5
shoulder pain 5
anorexia 4
starvation 4
Neurologic symptoms 4
chest pain 4
Rest tremor 4
jaw pain 4
excessive sweating 4
limb pain 4
hemihypesthesia 3
hypersomnia 3
heartburn 3
auditory hallucination 3
Ill 3
partial seizure 3
lightheadedness 3
hyperesthesia 3
regurgitation 3
rhinorrhea 3
Paroxysmal dystonia 3
tonic-clonic seizure 3
Postural tremor 3
Pyramidal signs 3
Limb dystonia 3
alexithymia 2
tense 2
joint stiffness 2
hyperemesis gravidarum 2
wheezing 2
bladder pain 2
hypocapnia 2
dysuria 2
eds 2
personality change 2
Motor dysfunction 2
Depressive symptoms 2
polyuria 2
Excitability 2
arthralgia 2
voice change 1
abnormal head movement 1
muscular incoordination 1
astasia 1
sneezing 1
cachexia 1
chronic cough 1
snoring 1
Acute dyskinesia 1
Action myoclonus 1
aphagia 1
more...
Drug
CSF 82
BoNT/A 73
DBS 64
Botox 55
BH4 41
lysine 37
BOTOX 25
Myobloc 23
Parkin 13
Parkin 13
Sinemet 13
Sinemet 11
vitamin E 11
caffeine 10
Sinemet 10
Apomorphine 10
Dermatol 10
Diphenhydramine 9
TMS 9
Diurnal 9
ABC 9
ENT 6
Madopar 6
NADH 6
Monit 6
L-tyrosine 5
nitroglycerin 5
Domperidone 5
Carbidopa 4
MRC 4
MDS 4
Phenytoin 4
Xanthium 4
Miglustat 4
Posture 4
9-THC 4
DEL 3
Cogentin 3
Sulpiride 3
Pramipexole 3
Duloxetine 3
Cogentin 3
Zonisamide 3
Rotigotine 3
Pramipexole 3
Vitamin E 3
Artane 2
HCH 2
Zmax 2
DMAP 2
Artane 2
Leaf 2
Azithromycin 2
Propofol 2
Modafinil 2
Remoxipride 2
Mirtazapine 2
Lioresal 2
Spectrum 2
MAP 2
IPD 2
Keppra 2
CTA 2
Clonidine 2
Riboflavin 2
Trental 2
Allergen 2
p75 1
NVP 1
Lactose 1
Ritalin 1
Solcoseryl 1
Retinoic acid 1
Flunitrazepam 1
Gemifloxacin 1
PTH 1
Thioridazine 1
Prednisone 1
Trimipramine 1
ROS 1
HCG 1
Adriamycin 1
Fenobam 1
pyridoxal phosphate 1
Spectrum 1
Mytelase 1
ROC 1
Galactose 1
Compazine 1
Akineton 1
Butamirate citrate 1
Frontal 1
CTX 1
GVG 1
Anafranil 1
Eculizumab 1
Tropicamide 1
Estrogens 1
Lisuride 1
citric acid 1
ampicillin 1
lactose 1
Flibanserin 1
Domin 1
Nephron 1
Gastro 1
Seletracetam 1
Compazine 1
Alanine 1
Anafranil 1
Dantrolene sodium 1
Inderal 1
Zyban 1
Ethanol 1
Geodon 1
CDX 1
Thyroglobulin 1
Torecan 1
Belimumab 1
PCP 1
Mytelase 1
Itraconazole 1
Triflupromazine 1
Cellcept 1
Ziprasidone hydrochloride 1
Premarin 1
Ouabain 1
Torecan 1
Fraction 1
ADM 1
Cloperastine 1
niacin 1
Clozaril 1
Histamine 1
Atropine 1
Geodon 1
Award 1
Vitamin B 1
Dilaudid 1
Check 1
Paliperidone 1
ascorbate 1
Reserpine 1
Donepezil 1
Prednisolone 1
Clebopride 1
Atomoxetine 1
CEC 1
Cellcept 1
Fluphenazine 1
Asn 1
ICI 1
Enzyme
botulinum neurotoxin 102
tyrosine hydroxylase 91
ATPase 91
GTP cyclohydrolase I 85
pantothenate kinase 44
complex I 39
glutaryl-CoA dehydrogenase 38
ceruloplasmin 29
cyclohydrolase 24
acetylcholinesterase 18
sepiapterin reductase 17
pyruvate dehydrogenase 14
creatine kinase 14
succinate dehydrogenase 12
hypoxanthine-guanine phosphoribosyltransferase 12
proteasome 12
DAT 11
beta-galactosidase 11
Alternating 11
monoamine oxidase 10
cytochrome oxidase 9
reverse transcriptase 9
pyruvate dehydrogenase 9
pyruvate dehydrogenase 9
cholinesterase 8
hexosaminidase 8
phospholipase A2 8
focal adhesion kinase 7
protein kinase 7
protein kinase C 7
phenylalanine hydroxylase 7
catalase 6
peroxidase 6
luciferase 5
tryptophan hydroxylase 5
dihydropteridine reductase 5
diaphorase 5
glutamate dehydrogenase 5
glutamate dehydrogenase 5
glutamate dehydrogenase 5
ERK 5
RNA polymerase 5
choline acetyltransferase 4
CD10 4
mitogen-activated protein kinase 4
ECH 4
superoxide dismutase 4
tetanus neurotoxin 4
ACE 4
caspase-3 3
PDH 3
adenosine deaminase 3
adenosine deaminase 3
NADH dehydrogenase 3
sulfatase 3
NO synthase 3
enolase 3
aspartate aminotransferase 3
kinesin 3
ATP synthase 3
NADH-cytochrome b5 reductase 3
cystathionine beta-synthase 3
transcriptase 3
DOPA decarboxylase 3
arylsulfatase A 3
acid phosphatase 3
Omi/HtrA2 2
deaminase 2
glutamate decarboxylase 2
kynurenine 3-monooxygenase 2
sulfite oxidase 2
sulfite oxidase 2
carbonic anhydrase 2
alpha-L-fucosidase 2
dopamine beta-hydroxylase 2
gamma-glutamyl transpeptidase 2
adenylate cyclase 2
methylmalonyl-CoA mutase 2
NADPH-diaphorase 2
PKG 2
HSD 2
CCS 2
BAT 2
guanylate cyclase 2
alkaline phosphatase 2
3-hydroxyisobutyryl-CoA hydrolase 2
CYP27A1 2
pyruvate carboxylase 2
fumarase 2
calcineurin 2
phosphoglycerate kinase 2
AST 2
glutathione reductase 2
lactate dehydrogenase 2
dihydrofolate reductase 2
catechol O-methyltransferase 2
aldose reductase 2
succinyl-CoA synthetase 2
alanine aminotransferase 2
6-pyruvoyltetrahydropterin synthase 2
alpha-L-fucosidase 1
asparaginase 1
glutamine synthetase 1
glycerol-3-phosphate dehydrogenase 1
NPL 1
ClpP 1
DNase 1
TOR 1
ubiquitin-protein ligase 1
tyrosinase 1
sialidase 1
CaMKII 1
Lod 1
matrix metalloproteinase 9 1
biotinidase 1
xanthine oxidase 1
PAH 1
lysin 1
MTD 1
arylsulfatase 1
sarcosine dehydrogenase 1
PCP 1
arginyl-tRNA synthetase 1
KAT 1
thioredoxin reductase 1
CPN 1
thyroid peroxidase 1
isocitrate dehydrogenase 1
GSK 1
SPC 1
polynucleotide kinase 1
arginase 1
caspase-8 1
isocitrate dehydrogenase 1
glutaminase 1
3-hydroxy-2-methylbutyryl-CoA dehydrogenase 1
pantothenase 1
thiamine pyrophosphokinase 1
neutrophil elastase 1
carbonyl reductase 1
diaphorase 1
alanyl-tRNA synthetase 1
pantothenase 1
transketolase 1
caspase-1 1
CPR 1
splicing endonuclease 1
aldehyde dehydrogenase 1
m-AAA protease 1
alpha-L-fucosidase 1
TPP 1
Mg2+-ATPase 1
C3 convertase 1
triphosphatase 1
lactase-phlorizin hydrolase 1
C3 convertase 1
calcium pump 1
E-2 1
neuraminidase 1
CAD 1
more...
Compound
Clin 635
Dec 541
L-DOPA 195
DNA 185
iron 141
Dopa 94
His 91
GABA 87
GABA 84
calcium 73
glucose 65
DBS 64
copper 64
glutamate 63
sodium 62
manganese 51
glutamic acid 46
MPTP 44
lysine 41
ATP 40
GTP 37
gamma-aminobutyric acid 34
tryptophan 33
tryptophan 33
tryptophan 33
tryptophan 33
ethanol 33
Botulinum toxin type A 31
water 31
oxygen 30
Pantothenate 29
tyrosine 27
Dopamine 27
Neuronal 27
potassium 26
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 26
zinc 25
5-HT 24
Baclofen 23
Clozapine 23
Phe 23
DSM 22
noradrenaline 22
Haloperidol 21
neopterin 21
Haloperidol 20
hydroxyindoleacetic acid 19
alanine 18
hydroxyglutarate 18
nitric oxide 17
CIT 17
CIT 17
valine 16
Olanzapine 15
HVA 15
CoA 15
arginine 15
5-hydroxytryptophan 15
methionine 15
Cereb 14
CO2 14
Risperidone 14
AAA 13
Ile 13
AMPA 13
leucine 12
threonine 12
glutamine 12
Trihexyphenidyl 11
isoleucine 11
isoleucine 11
Metoclopramide 11
phenol 11
DAT 11
glutaryl-CoA 10
Tetrahydrobiopterin 10
phosphate 10
Optimal 10
Allergan 10
caffeine 10
Aripiprazole 9
5-HIAA 9
silver 9
cysteine 9
Isoproterenol 9
cyanide 9
GA1 9
hydrogen 9
Neurotol 9
PSP 9
Diphenhydramine 9
galactose 8
NMDA 8
benzamide 8
3,4-dihydroxyphenylalanine 8
Diazepam 8
Tetrabenazine 8
butyric acid 7
creatinine 7
pteridine 7
Ziprasidone 7
butyric acid 7
butyric acid 7
IMP 7
MTS 6
serine 6
GM1 6
DDP 6
piperidine 6
Thiamine 6
NADH 6
Off 6
piperidine 6
Bromocriptine 5
Amantadine 5
NPA 5
A 42 5
DPH 5
PDQ 5
Amphetamine 5
Biperiden 5
acetate 5
Amphetamine 5
Acetazolamide 5
Cocaine 5
Amantadine 5
ammonium 5
A 3 5
CAA 5
Clonazepam 5
Amantadine 5
Amantadine 5
proline 5
PTS 5
ADP 5
6-12 4
EDTA 4
homocysteine 4
pyridine 4
Muscimol 4
Biopterin 4
carbonate 4
NBQX 4
L-carnitine 4
Glutamate 4
Asp 4
Gly 4
Stimul 4
DDC 4
ADP 4
barium 4
TSH 4
acetic acid 4
PAS 4
Elan 4
LTD 4
GM2 4
coenzyme Q10 4
MEP 4
MEP 4
more...