Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have observed a high incidence of ulnar neuropathy in musicians with dystonic flexion of the ipsilateral little and ring fingers. To investigate the relationship between ulnar neuropathy and focal dystonia, we compared the patterns of surface EMG activity in extensor digitorum communis (EDC4) and flexor digitorum superficialis (FDS4) during tapping of the ring finger in normal controls and patients with ulnar neuropathy or focal dystonia. Ten of 10 normal subjects exhibited well-formed alternating EMG bursts in EDC4 and FDS4 separated by clear silent periods. Seven of 7 patients with dystonic flexion of the little and ring fingers showed loss of silent periods between poorly formed bursts in FDS or EDC. Surprisingly, 9 of 10 patients with ulnar neuropathy showed burst pattern abnormalities qualitatively similar to those observed in the dystonic patients. These data suggest that ulnar neuropathy alters the execution of a motor task involving multiple peripheral nerves.
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PMID:Does ulnar neuropathy predispose to focal dystonia? 775 23

A patient affected by thoracic outlet syndrome, with an involvement of the left lower primary trunk due to a rudimentary cervical rib, developed a severe hand dystonia on the same side. The dystonic posture was characterised by a flexion of the wrist with the fingers curled into the palm. Polygraphic recordings performed on the left flexor digitorum superficialis (FDS4) and extensor digitorum superficialis (EDC4) muscles, during a repetitive tapping task of the fourth digit, showed a loss of well formed bursts without a clear silent period along with long duration bursts of cocontraction in antagonistic muscles. The study of reciprocal inhibition between forearm flexor and extensor muscles showed a reduced amount of inhibition in both the disynaptic and the later presynaptic phase of inhibition. The patient underwent an operation with resection of the cervical rib. Twelve hours after the operation the patient experienced a significant improvement of the hand dystonia; the distonia had disappeared completely by two months with a progressive normalisation of reciprocal inhibition.
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PMID:Focal hand dystonia in a patient with thoracic outlet syndrome. 970 90