Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0013421 (
dystonia
)
8,418
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
CI-943 is a new drug candidate with antipsychotic-like activity in a variety of behavioural tests in rodents and primates, but without any affinity for brain dopamine receptors. CI-943 does not cause
dystonia
in monkeys, a predictive symptom of extrapyramidal side effects (EPS). Its mechanism of action remains unclear.
Neurotensin
(NT) concentration in nucleus accumbens and caudate is increased by CI-943; this may be associated with its antipsychotic effect. Indeed various observations suggest that the clinical action of antipsychotic drugs may at least be partially mediated by some neuropeptides. Various actions of
neurotensin
are reviewed. The hypothesis on the role of
neurotensin
represents a new strategy in the development of pharmacological tools for the treatment of schizophrenia.
...
PMID:Antipsychotics and neuropeptides: the atypical profile of CI-943 and its relationship to neurotensin. 868 14
