Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The suggested mode of treatment combines the intravascular laser-light irradiation of blood with the visual analyzer exposure to light the brightness of which changes evenly and rhythmically with a frequency of 7-8 vibrations per minute (0.13 Hz). The combined use of the aforementioned exposures is justified due to the fact that exposure to both ionizing radiation and psychogenic factors play an important role in the pathogenesis of vegetovascular dystonia developing in the liquidators of the Chernobyl Atomic Power Plant breakdown. Change of lighting makes for the evolution of the inhibitory process in the cortex, has a sedative effect, attenuates the influence of psychotraumatizing factors. Intravascular laser-light irradiation of blood has a beneficial effect upon the organism's reactivity and immune system. Under the influence of the therapy adopted, all patients in present series (n = 67)--liquidators of the Chernobyl APP breakdown, suffering from VVD, demonstrated beneficial shifts both in the vegetovascular reactions and immune status, as evidenced by the analysis of the results of the presented mode of treatment in this patient population.
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PMID:[The nondrug treatment of patients with autonomic vascular dystonia subjected to ionizing radiation exposure as a result of the accident at the Chernobyl Atomic Electric Power Station]. 760 85

Deficiency of caytaxin results in hereditary ataxia or dystonia in humans, mice and rats. Our yeast two-hybrid screen identified kinesin light chains (KLCs) as caytaxin-binding proteins. The tetratricopeptide-repeat region of KLC1 recognizes the ELEWED sequence (amino acids 115-120) of caytaxin. This motif is conserved among BNIP-2 family members and other KLC-interacting kinesin cargo proteins such as calsyntenins. Caytaxin associates with kinesin heavy chains (KHCs) indirectly by binding to KLCs, suggesting that caytaxin binds to the tetrameric kinesin molecule. In cultured hippocampal neurons, we found that caytaxin is distributed in both axons and dendrites in punctate patterns, and it colocalizes with microtubules and KHC. GFP-caytaxin expressed in hippocampal neurons is transported at a speed ( approximately 1 mum/second) compatible with kinesin movement. Inhibition of kinesin-1 by dominant-negative KHC decreases the accumulation of caytaxin in the growth cone. Caytaxin puncta do not coincide with vesicles containing known kinesin cargos such as APP or JIP-1. A part of caytaxin, however, colocalizes with mitochondria and suppression of caytaxin expression by RNAi redistributes mitochondria away from the distal ends of neurites. These data indicate that caytaxin binds to kinesin-1 and functions as an adaptor that mediates intracellular transport of specific cargos, one of which is the mitochondrion.
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PMID:Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains. 1986 99