Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Paroxysmal dystonia (PD) is a usually painful, unilateral dystonic posture, precipitated by voluntary movement, tactile stimulation, startling noise or hyperventilation. We describe two cases of paroxysmal dystonia in multiple sclerosis, both with a critically localized lesion in the thalamus, contralateral to the paroxysmal symptoms. Only one other case of paroxysmal dystonia with a demyelinated lesion of the thalamus has been reported previously.
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PMID:Paroxysmal dystonia with thalamic lesion in multiple sclerosis. 1191 77

Paroxysmal phenomena such as dystonia in multiple sclerosis (MS) have approximate incidence ranged between 3.8%-17%. These symptoms in MS may represent transient phenomena related to inflammation in acute plaques and probably are secondary to irritation of demyelinated axons by lymphokines. Paroxysmal dystonia can occur at any time during the course of MS, but usually is the initial manifestation of demyelinating disease. We present the case of 42-year old woman with paroxysmal dystonia as the initial symptom of MS. Further MRI studies and CSF analysis revealed findings typical for MS. Patient's neurological status improved temporary after methyloprednisolone therapy. Paroxysmal dystonia may be related to ectopic impulses, release of inflammatory soluble factors, dysfunction of ion channels and accumulation of extra-cellular potassium. Paroxysmal dystonia often causes diagnostic difficulties, especially when it is the only or the initial symptom of the disease. It requires differential diagnosis with other diseases of central nervous system such as epilepsy and neurodegenerative or inflammation pathology.
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PMID:[Paroxysmal focal dystonia as the initial manifestation of multiple sclerosis: case report]. 1509 39

Tremor is the most common and frequently reported movement disorder in multiple sclerosis (MS). Paroxysmal dystonia (PD), also known as painful tonic spasm (PTS), is a relatively less common but well-recognized movement disorder in multiple sclerosis (MS). These are characterized by episodic attacks of involuntary flexion, extension movements of body. Such paroxysmal symptoms as an initial presenting feature raise many differential diagnoses and can often be mistaken as epileptic seizures as well as psychogenic events and may sometimes lead to delay in diagnosis as well. Diagnosis is clinical with the help of supportive investigations to rule out other paroxysmal disorders, especially epileptic seizures. We describe a case of a young lady, who was referred to us as a case of refractory seizure and diagnosed as having paroxysmal dystonia as a first manifestation of MS, with complete resolution of her symptoms after successful treatment with anti-epileptic drugs.
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PMID:Paroxysmal dystonia as an initial presentation of multiple sclerosis posing a diagnostic challenge. 3138 Aug 25