Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Early ECG and Bcg changes in workers exposed to lead have been described. The changes are a consequence of disturbed myocardial metabolism, momentary coronary spasms and neurovegatative dystonia.
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PMID:Ballistocardiographic and electrocardiographic changes in men working with lead. 113 Nov 61

The authors describe 14 personal cases of progressive supranuclear palsy, 8 of them including a neuropathological study. The analysis of this material confirms the characteristics of this nosological entity, which is now well individualized amongst the apparently idiopathic degnerative diseases of the CNS. The clinical picture was characterized in all cases by a supranuclear opthalmoplegia, a pseudo-bulbar syndrome, an axial dystonia and a 'subcortical' dementia of a particular type. The average duration of the disease was 4 years for the 12 patients followed until death; the first symptoms appeared at a slightly older age than the average reported in the literature. Males are not predominantly affected in our material. Lesions are remarkably homogeneous as to their localisation in all cases but one. The nuclei of cranial curves are moderately involved, the reticular substances throughout the brain stem is more severely effected. In two cases, senile degenerative lesions of the cerebral cortex are associated with subcortical lesions of the progressive supranulcear palsy. No anamnestic or histologic feature is suggestive of any etiology of this disease. L-Dopa with or within a Dopa-decarboxylase inhibitor did after alter neither the patients condition nor the course of the disease.
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PMID:[Supranuclear progressive paralysis (or oculo-facial-cervical dystonia)]. 115 60

The present report discusses two patients of a same family who have "familial progressive dystonia with diurnal fluctuation" (Segawa). One of them, a severely handicapped nine year-old girl was successfully treated with L-Dopa.
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PMID:[Familial progressive dystonia with diurnal fluctuation. Case report. Remarkable therapeutic effect of 1-dopa (author's transl)]. 116 24

We have demonstrated that injection of manganese into one caudate nucleus in rats results in a predominant ipsilateral turning behavior, accompanied at higher doses by an intermittent, alternating and dose-related incidence of contralateral turning and stereotypies. Although the pharmacological evidence produced (effect of alpha-MT, L-DOPA, pargyline) indicates a definite participation of the dopaminergic system in the latter two phenomena, it is probable that ipsilateral turning is the result of involvement of other transmitter systems as well. Tegmental serotoninergic and intrastriatal cholinergic pathways appear to be involved in the production of the basic postural asymmetry resulting in turning. The amount of interference with the nigrostriatal and mesolimbic dopaminergic pathways may determine the speed of circling, and the concurrent inhibition of locomotion. This is more evident with bilateral injections. Manganese appears to act at presynaptic levels within the striatum by blocking release of the transmitter, thus creating a localized, relative deficit in caudate function. The end result is the release of the dominant "ipsilateral syndrome-inducing system' from its inhibitory control. Repeated or chronic administration of this metal in man or animals is known to result in a brain dopamine and/or serotonin deficit commensurate with the clinical manifestations of bradykinesia and dystonia. Our results are compatible with the anatomical findings of Poirier and collaborators and tend to support the dual ipsilateral and contralateral syndrome-inducing systems in the caudate postulated by Cools, and the complementary roles of dopamine, serotonin and acetylcholine within that nucleus. No one transmitter is involved alone in the experimental production of the manganese syndrome, or of its component symptoms.
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PMID:Behavioral effects in rats following intrastriatal microinjection of manganese. 117 15

The presented results illustrate the study of the cardiovascular system by means of radiocardiography conducted in normal individuals working in contact with sources of ionizing radiation. The study includes 51 persons in the test group and 42 in the control group that was similar to the test one in terms of age, sex and type of work performed, with the only exception that these in the control group had no contact with ionizing radiation. Persons working under the effect of ionizing radiation displayed a moderate increase in the stroke and minute index and the circulating blood volume, with the blood flow rate somewhat decelerated. The changes were deeper in those with over 5 years of service, and in those with functional changes in the nervous system, like neurocirculatory dystonia. The moderate level of these reactions and their reversibility permit to interpret them as an adaptative reaction to the effect of low doses of ionizing radiation.
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PMID:[State of hemodynamics, according to radiocardiographic data, in persons working in contact with ionizing radiation sources]. 119 39

The diagnostic value of ST-T changes in working ECG on veloergometer with submaximal loading is assessed in 286 cases--83 with coronary disease, 44--healthy, 112 with indistinct precordial pains and neurovegetative dystonia and 46 with some other non-coronary heart diseases. The reduction of ST-segment 1 mm with horizontal or descending form is the most accurate criterium in the differentiation of pathological and normal ECG-reactions. An appropriate criterium for coronary disease diagnosis is also the negative T wave with an amplitude of 2 mm or more in at least three leads, regardless of its form and time of appearance. The reduction of ST segment with ascending form gives a considerable opportunity for positive false diagnosis. The false negative diagnosis is 24%. The causes are to be found in the appearance of rhythm and lead disturbances and insufficient loading.
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PMID:[Diagnostic value of the electrocardiographic changes during bicycle ergometer loading]. 122 20

The author assessed the results of the test of the triiodothyronine (T3) suppression of the I131 absorption in 10 healthy women, 22 suffering from neurocirculatory dystrophy and 35 patients with diffuse toxic goiter. This test was found to distinctly differentiate the patients with diffuse toxic goiter and healthy persons. Reduction of absorption to the level below 15% of the indicator dose with consideration to the level of the initial absorption could be considered as criterion of the normal I131 absorption in response to the T3 administration. The mean suppression of the absorption in T3 administration in patients with neurocirculatory dystonia (10.7 +/- 1.49%) displayed a significant difference from the level of mean suppression of the absorption in patients with diffuse toxic goiter (58.1 +/- 4.76%). However, in individual patients suffering from neurocirculatory dystonia the I131 absorption by the thyroid gland in T3 administration still exceeded such in healthy persons. Therefore such patients require further observation because of a possible development in them of diffuse toxic goiter.
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PMID:[Criteria of the test of suppression of thyroid uptake of I131 by triiodothyronine]. 124 28

Glutaric aciduria is a disorcer of lysine, tryptophan, and hydroxylysine metabolism characterized by intermittent metabolic acidemia, dystonia, athetosis and mental retardation. It is due to a recessively inherited deficiency of glutaryl-CoA dehydrogeanse, the enzyme(s) which catalyze the dehydrogenation of glutaryl-CoA to glutaconyl-CoA and decarboxylation of the latter to crotonyl-CoA. Abnormal quantities of glutaric, beta-hydroxyglutaric, and glutaconic acids are found in the urine of these patients. The nature of the movement disorder prompted study of the effects of the abnormally excreted metabolites on brain glutamate decarboxylase, an enzyme implicated in the pathogenesis of Huntington's chorea. Glutamate decarboxylase activity was examined in rat and rabbit brain acetone powders, stabilized with pyridoxal phosphate and glutathione. Glutarate, beta-hydroxyglutarate, and glutaconate were competitive inhibitors of this emzyme, Ki values being 1.3 X 10(-3) mol/l, 2.5 X 10(-4) mol/l, respectively. This inhibition may explain the neurological accompaniments of this syndrome.
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PMID:Inhibition of brain glutamate decarboxylase by glutarate, glutaconate, and beta-hydroxyglutarate: explanation of the symptoms in glutaric aciduria? 124 44

Advances in the understanding of the relationship of proprioceptive (kinesthetic) feedback to motor physiology have prompted the study of therapeutic effects of audiovisual displays of EMG activity. Patients with various manifestations of disturbed neuromotor control were studied prospectively for three years. This group included 114 patients with hemiparesis, torticollis, dystonia, and spinal cord or peripheral nerve injury. Initially, all but one of these patients had some residual volitional motor activity, which was insufficient for adequate function, and all patients had had conventional therapy with little or no functional recovery. Prior to EMG feedback therapy, the duration of illness was from three months to 35 years. The shaping of a patient's motor responses usually occurred gradually, often over an 8 to 12 week period. This modification was accomplished by feeding processed audio-visual signals back to the patient. These signals were proportional to the degree of activity of the muscles responsible for the defective function. The concept of microvolt-second, as a unit of muscle activity, is introduced and defined. Patterned movements, which were previously defective were observed to improve to varying degrees. Following the initial course of treatment, reinforcement was required by some patients. The mechanisms of improvement after EMG feeback therapy are not well understood; however, some hypotheses are presented. The results of this study indicate that EMG feedback therapy may induce significant functional recovery in patients with disturbed neuromotor control.
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PMID:EMG feedback therapy: review of treatment of 114 patients. 125 43

The antiarrhythmic efficacy of the anticonvulsant sodium valproate was studied in 22 patients with ventricular premature contraction in the immediate (10-15 days) and late (2-5 months) periods of therapy. The prolong antiarrhythmic effect of the drug was observed in 66% of the patients in whom it was beneficial in the first days of therapy. The results obtained provide strong evidence for the efficacy of sodium valproate in patients with ventricular premature contraction occurring in the presence of neurocirculatory dystonia.
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PMID:[The anti-arrhythmic efficacy of sodium valproate]. 128 79


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