Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The therapeutic effectiveness of sulpiride on various types of neurosis was compared with that of chlordiazepoxide on a double-blind basis. Global improvement, effectiveness on various types of neurosis, and side effects were studied for a period of two weeks. The subjects consisted of 41 males and 32 females. Neurosis including borderline case and vegetative dystonia was divided into eight different subtypes comprising borderline, neurasthenic state, hypochondria, obsessive neurosis or phobia, depressive neurosis, anxiety neurosis, vegetative dystonia, and others. A newly devised matched-pair method of comparison was employed to achieve even distribution of the eight subtypes of neurosis between the two drug groups. As a result 40 patients fell in the sulpiride group and 33 patients in the chlordiazepoxide group. The backgrounds of the paired patients matched closely. The daily dose was uniformly 150 mg for sulpiride and 30 mg for chlordiazepoxide in the first week but was raised (or lowered in some cases) to 225 mg and 45 mg, respectively, in the second week according to severity. The rate of global improvement was 79% for the sulpiride group and 90% for chlordiazepoxide group, and the difference did not reach statistical significance. Improvement by manifestation (13 symptom items) and type of neurosis also matched. Side effects occurred at a rate of 28% (sulpiride group) and 30% (chlordiazepoxide group), and also matched closely in incidence and variety. The authors concluded that sulpiride in appropriate doses is useful in the treatment of neurosis without causing extrapyramidal side effects.
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PMID:A double-blind comparison of sulpiride with chlordiazepoxide in neurosis. 78 20

The paper provides findings from an examination of 26 patients with neurocirculatory dystonia (NCD) with the hypertensive syndrome, 18 with NCD of the cardiac type (neurocirculatory asthenia), and 10 healthy subjects. Application of original psychological questionnaires made it possible to detect anxiety neurosis in a cardiac variant of NCD and neurosis with marked conversion in a hypertensive variant of NCD. In the latter, there was an increase in Na+/H+ and Li+/Na+ countertransport rates in the erythrocyte membrane, which was typical of essential hypertension. In the former variant, the Na+/H+ countertransport rate was lower in the erythrocyte membrane than that in the controls, whereas no differences were found in Li+/Na+ countertransport rates between the cardiac NCD patients and the controls.
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PMID:[Characteristics of neurotic state and transmembrane transport of sodium in erythrocytes in hypertensive and cardiac variants of neurocirculatory dystonia]. 239 12