Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirteen patients with acute dystonia and extrapyramidal symptoms as a result of drug intoxication are reported. In a number of instances, the symptoms were due to more than one drug being given to the patient, among which were phenothiazine derivatives, non-phenothiazine tranquilizers and metoclopramide. Diazepam (Valium) given intravenously caused the patients to fall asleep immediately and to wake within an hour, free from all symptoms. It is felt that in patients with drug-induced extrapyramidal symptoms, diazepam should be considered as the possible drug of choice.
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PMID:Treatment with diazepam of children with drug-induced extrapyramidal symptoms. 44 94

Clinico-neurologic and electroencephalographic (EEG) examinations of 149 women suffering from late gestosis, carried out during pregnancy and after labor, have revealed various neurologic syndromes (vegetovascular dystonia, narcoleptic and neuroendocrine syndromes, pyramidal insufficiency syndrome) in all of them; these syndromes correlated with the severity of late gestosis and EEG changes. The detected changes indicated the presence of the hypothalamic syndrome in women suffering from late gestosis, this syndrome being more marked in grave forms of gestosis. The detected neurologic symptoms and EEG changes persisted long after delivery (up to 7 years). The authors emphasize the necessity of timely adequate therapy of women suffering from gestosis, that should include tranquilizers, anticonvulsants, vasoactive and nootropic drugs.
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PMID:[Clinico-neurological and encephalographic aspects of toxicosis in late pregnancy]. 195 46

Diagnosis of dystonia is not difficult by recognizing the pattern of clinical presentation. Dopa-responsive dystonia (DRD) and Wilson disease are important in differential diagnosis because of their specific treatment. The most common are the focal dystonias, including blepharospasm and spasmodic torticollis. Dystonia comprises mobile involuntary movements and abnormal postures, the latter is better described as hypokinetic disorder. The pathogenesis of dystonia is now being clarified, and includes abnormal neuroplasticity caused by the relative excess of dopamine in the matrix compartment of the striatum, the possible primary lesion being the striosome. In a dopa-responsive dystonia model, dopaminergic projection is more deficient to the striosome than to the matrix, which could produce imbalance between the direct versus. indirect pathway activities. The treatment options include trihexyphenidyl, minor tranquilizers, botulinum toxin injection, and deep brain stimulation.
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PMID:[Diagnosis and treatment of dystonia]. 1919 96