Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Quantitative indices of instantaneous maps of the distribution of electric potential on the chest surface were compared to a left ventricular myocardial mass value, calculated on the basis of echocardiographic results and echocardiographic signs of left ventricular hypertrophy, in 77 patients with essential hypertension or neurocirculatory dystonia of hypertensive type and in 25 healthy controls. Four quantitative cartographic indices were shown to be very important for diagnosis: 1) tMaxk; 2) tapic; 3) + sigma QRS; 4) NQ15. The sensitivity, specificity and accuracy of diagnosis of left ventricular hypertrophy was over 80%. Cartographic quantitative indices were shown to correlate with a high degree of significance (p less than 0.01) (r much greater than 0.75) with a left ventricular myocardial mass value calculated on the basis of echocardiography results.
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PMID:[Early diagnosis of left-ventricular hypertrophy using precordial electrocardiographic mapping of the heart]. 297 72

This review presents the data of assessing antihypertensive efficacy and tolerability vasoselective high-lipophilic the 3d generations calcium channel blocker lercanidpine. The inhibition of the calcium ions flow through the membranes of smooth muscle cells of blood vessels causes peripheral, cerebral, renal and coronary vasodilation decreasing total peripheral vascular resistance and, consequently, blood pressure (BP) lowering and improve regional circulation. During reception of lercanidipine the level of norepinephrine remains the same even when using high doses of the drug. Negative inotropic effect does not occur therefore, lercanidipine can be used in the treatment of myocardial ischemia. Renal protection properties slow down the development and progression ofchronic renalfailure (CRF). The drug can be successfully used in patients with arterial hypertension, chronic renalfailure, diabetic and non-diabetic nephropathy. Lercanidpine also may be effectively used in the treatment of hypertension with associated clinical conditions: bronchial asthma, chronic obstructive pulmonary disease, bradiarrythmias, atrioventricular blockade 2-3 degree, sinus node dysfunction, peripheral arteries deseases with symptoms of the extremities ischemia, sleep disturbance, depression, dystonia, asthenic and cephalgic syndme in the frame of the cerebrovascular insufficiency manifestations. Therapy with lercanidpine, in addition to lowering blood pressure, can help to nephroprotection, neuroprotection, antianginal effect, the regression of left ventricular hypertrophy, improvement of lipid metabolism and glucose tolerance. With over 30 years experience in the application and modification of the molecular structure, slow the onset of action and superior long-lasting effect reception of letranidipine well-tolerated and provides a high adherence ofpatients to the treatment of hypertension.
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PMID:[THE ROLE PLEIOTROPIC EFFECTS OF CALCIUM CHANNEL BLOCKER LERCANIDIPINE IN PERIOPERATIVE THERAPY OF ARTERIAL HYPERTENSION.] 2948 11