Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Studies are reported of the variation of melatonin in serum, plasma urine and cerebrospinal fluid in normal subjects and in patients with various diseases. The diurnal variation of plasma and urine melatonin found in healthy controls on a regular dark-sleep pattern persisted when the subjects slept in light. The effect of sleep deprivation and of rapid light exposure at night is reported. There was a correlation between melatonin in morning urine and plasma at 2 a.m. Four hours of extended darkness in the morning as well as a 9-hour shift of sleep and activity cycles following travel affected the melatonin rhythm. The night increase in plasma melatonin preceeded both the cortisol and prolactin rise. A single oral dose of 4.3 X 10(5) nmol of melatonin given to a 44-year-old healthy male gave a peak plasma value of 624 nmol/l after 30 min. Plasma melatonin was not affected by electroconvulsive therapy, TRH-injection, L-Dopa or bromoergocryptine orally. Patients with alcoholism, migraine, postoperative pinealoma, panhypopituitarism, hereditary dystonia and schizophrenics on propranolol exhibited a decreased amplitude of their diurnal rhythm of melatonin. Two patients with pituitary tumors had occasional high levels of plasma melatonin. The change in melatonin secretion in human is apparently controlled by a mechanism which is at least party influenced by environmental lighting conditions, drugs and different disease states.
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PMID:Melatonin in humans physiological and clinical studies. 38 89

We report here an autopsy case, an 8-year-old boy diagnosed as having infantile striatal necrosis, characterized by a preceding febrile illness followed by acute encephalopathy with abrupt obtundation, seizures and dystonia, with remarkable improvement of the disturbed consciousness and intelligence after TRH-T therapy. These clinical symptoms were linked with bilateral necrosis of the striata on CT scanning. The presented case belonged to a newly described subgroup of the heredogenous disorders that produce necrosis of the putamina in children.
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PMID:A case report of infantile striatal necrosis with an acute onset. 310 77

A comparative analysis of thyroid and calcium regulating functions in the diffuse toxic goiter was performed. At the initial stage TSH reaction to TRH was on a decrease in parallel with a sharp increase in the content of T4 T3. Two-third of the patients revealed an increase in the level of calcitonin resulting in an increase in the ratio of calcitropic hormones. In that case the content of ionized calcium was not increased. In one-third of the patients the level of calcitonin showed a tendency to a decrease in the normal ratio of calcitropic hormones not accompanied by change in the level of ionized calcium. In neurocirculatory dystonia polymorphism of clinical manifestation was accompanied by great variations (both rising and lowering tendencies) of all indices.
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PMID:[Interrelation of the thyroid and calcium-regulating functions in patients with diffuse toxic goiter]. 342 31