Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

ECG data obtained with a Holter monitor in a group of 90 adolescent patients with vegetovascular dystonia and sick sinus syndrome (SSS) showed that mexidol, intravenously instilled in a daily dose of 2-4 mg/kg over a period of 10 days in combination with a standard neurometabolic scheme results in the development of a therapeutic effect in 93-100% of patients with clinical-ECG variants I and II of the disorder. In most cases, both clinical state and ECG quality were improved and the functional capacity of myocardium was increased. Repeated courses of mexidol administration increased efficacy of the ambulatory SSS treatment on the average by 20%.
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PMID:[Effect of mexidol on efficacy of traditional therapy of sick sinus syndrome in adolescents]. 1465 Feb 10

Liquidators of consequences of the Chernobyl atomic power station accident were found to have cardiovascular regulatory disorders in the late period. A late pressure reaction of systolic blood pressure to exercise was caused by cardiac rhythm rigidity due to the sick sinus syndrome. High exercise tolerance and delayed ischemia were indicative of diminished total peripheral resistance due to the impaired responsiveness of alpha-adrenoblockers in the arterial vessels and of the development of neurocirculatory dystonia. Cardiovascular functional changes in the liquidators are not attended by the higher morbidity rates of hypertensive disease.
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PMID:[The cardiovascular system in liquidators of consequences of the Chernobyl atomic power station accident]. 1534 87