Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In addition to the traditional preoccupation for accurate localization of lesions, a new trend in our discipline emphasizes therapeutic approaches to various neurological disorders. This review summarizes the result of multi-center trials that we personally participated during the past decade to present an overview of the current thought in the area of our interest. The disorders in question include dystonia, chronic inflammatory demeyelinating polyneuropathy, myoclonic epilepsy, diabetic polyneuropathy, amyotrophic lateral sclerosis, and experimental allergic neuritis. These results and other equally encouraging data suggest that we are not necessarily fighting a loosing battle in dealing with these incapacitating diseases, even though our effort often falls short of achieving a complete cure. In formulating a list of differential diagnosis, we must always entertain the possibility of remedy as the eventual goal of our clinical practice.
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PMID:[Therapy oriented neurology from repair to remedy]. 1034 32

Spasmodic torticollis or cervical dystonia (CD) is the most common form of focal dystonia and is characterized by sustained abnormal muscle contractions in the head and neck area resulting in abnormal positioning or posturing of the head. The dystonic muscle spasms associated with spasmodic torticollis may affect any combination of neck muscles. Three cases are reported of spasmodic torticollis that were treated by a dental appliance with individual varying occlusal heights to open the maxillomandibular vertical dimension. Upon increasing the vertical dimension of occlusion, there was a slowing and/or discontinuance of the symptoms of cervical dystonia. The proposed hypothesis for this reversal is that there may be neuritis of the auriculotemporal branch of the trigeminal nerve, which has direct input into the reticular formation (RF), and it may activate the cells of the pontine region of the RF known for the control and deviation of head posture. There is growing clinical evidence that temporomandibular joint (TMJ) dysfunction may be a factor in this neurological and painful disorder when it coexists.
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PMID:Spasmodic torticollis: the dental connection. 2291 71