Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The rheologic properties of blood were studied in 40 patients with ischemic heart disease both with affected and with intact cardiac coronary arteries (according to the findings of angiography) and in 13 persons with cardialgia due to vegetovascular dystonia. Significant hemorheologic pathology according to all values was revealed in patients with ischemic heart disease. It was noted that the growth of the fluidity threshold depends on the developing pathologic erythrocyte aggregation which is not associated with changes in the concentration of plasma fibrinogen. The importance of disorders in blood rheology in the origin of angina pectoris and myocardial infarction is discussed.
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PMID:[Rheological properties of the blood in ischemic heart disease]. 69 50

The profile of functional sensomotor asymmetry (FSMA) was evaluated by a series of tests and inversion of emotional reflection. Altogether 70 healthy subjects and 114 cardiovascular diseases patients were examined. Among the patients there were 36 subjects with acute myocardial infarction, 28 with coronary heart disease, 26 with borderline hypertension and 24 with neurocirculatory dystonia (NCD). The highest emotional tension was recognized in myocardial infarction and coronary heart disease. NCD patients exhibit the left FSMA profile more frequently than healthy subjects.
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PMID:[Analysis of the profiles of functional psychomotor asymmetry and mental stress in patients with cardiovascular diseases]. 176 50

The analysis of clinical pattern, psychovegetative disturbances and metabolic defects in coronary patients with a history of myocardial infarction at young age provided information for recognition of two subgroups: normal-weight and overweight patients. Metabolic derangement manifesting with high total cholesterol and triglycerides levels occurred in group II whereas dystonia was registered in both groups as shown by assessment of reactivity and vegetative tone. Background parasympathetic activation and sympathoadrenal activation in exercise grew. Overweight patients seemed to have a marked vegetative dysfunction. The two patterns established have both theoretical and practical significance in terms of design of therapeutical measures.
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PMID:[Psychoemotional condition and autonomic nervous system in patients suffering from myocardial infarction in the young age]. 187 10

The study was undertaken to examine 35 patients with chronic coronary heart disease and 20 patients with neurocirculatory dystonia concurrent with the cardialgic syndrome, the latter were enrolled into a control group. Detection of sigma R in the standard leads of resting ECG and at the peak of atrial pacing made it possible to single out groups of chronic coronary heart disease patients, which differed in clinical manifestations of the disease, myocardial contractility, hemodynamics, and myocardial lactate extraction. In patients with chronic coronary heart disease ti is recommended to use ECG measurements (sigma R and nST) in the standard leads during loading tests to give a comprehensive characterization of the pump function and the severity of myocardial ischemia, the prognosis of the natural history of the disease and risk for myocardial infarction. To enhance the sensitivity and specificity of loading tests, it is recommended to take into account higher sigma R in combination with ST segment depression when the results of the tests are assessed.
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PMID:[Diagnostic and prognostic value of quantitative indicators of 12 ECG leads in ischemic heart disease]. 223 66

A study of 70 teenagers between 11 and 15, whose parents had suffered, before they were 45, myocardial infarction in the presence of verified coronary arterial atherosclerosis, revealed no organic cardiac changes, while some signs of neurocirculatory dystonia were combined with increased incidence of coronary risk factors and dyslipoproteinemia.
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PMID:[Functional status of the cardiovascular system of adolescents with a hereditary predisposition to atherosclerosis]. 295 50

The proportion of apoprotein-AI (apo-AI) phospholipids (PL) and HDLP phospholipid spectrum were determined in addition to principal coronary risk factors; cholesterol (CS), triglycerides (TG) and high-density lipoprotein (HDLP) CS, in high-risk children, whose parents had survived myocardial infarction at a young age, and also in children with vegetovascular dystonia and a control group. It is demonstrated that children with relatively low percentage of lecithin in HDLP, in the absence of changes in CS, TG, apo-B and apo-AI, and HDLP CS, could be found in all the examined groups, and were particularly numerous in the high-risk group. Correlations coefficients for the HDLP PL percentage in the father-child, mother-child and father-mother pairs were estimated, revealing a positive correlation with respect to lecithin in these pairs, an evidence of the contribution of the general familial environment to the variability of the parameter in question in the examined groups. Different correlations were demonstrated between lecithin/sphingomyelin and lecithin/kephalin ratios in boys and girls from the control and high-risk groups.
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PMID:[Changes in phospholipid composition of high density lipoproteins in children as a possible precursor of the development of ischemic heart disease]. 323 48

Ninety-eight men were examined. Of these, 13 were practically healthy, 29 had vegetovascular dystonia, 15 stable angina pectoris, and 41 men suffered myocardial infarction. Each group was appraised for work fitness. The double product, work, chrono- and inotropic reserves of the heart, as well as the index of energy losses of the heart per unit of work were calculated. A significant decrease in chrono- and inotropic reserves of the heart were revealed in patients with demonstrable coronary pathology and with cicatricial lesions after myocardial infarction. The patients with vegetovascular dystonia showed inadequate response to the exercise, manifested by greater energy losses of the heart per unit of work as compared to normal.
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PMID:[Comparative study of the exercise tolerance of patients with autonomic circulatory dystonia, angina pectoris and previous myocardial infarction]. 649 7

Algesimetry was used to study the pain sensitivity in 143 subjects (21 healthy individuals, 20 cases with neurocirculatory dystonia, 62 with chronic ischaemic heart disease and 40 with subacute myocardial infarction). The tests were performed for the tactile threshold, pain threshold, threshold of pain endurance and the interval of pain endurance. In a part of patients indices of pain sensitivity were correlated with tolerance to physical exertion. In neurocirculatory dystonia high pain sensitivity was due to the lowering of the pain threshold. In patients with ischaemic heart disease there were three types of pain threshold (low, medium, high) and two variants as concerns the interval of pain endurance (low and high). Low interval of pain endurance corresponded to low tolerance of physical exertion, hence algesimetry can serve as an additional method of objective interpretation of the bicycle ergometry tests.
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PMID:[Algesimetry in ischemic heart disease and neurocirculatory dystonia]. 732 24

The hypothalamus was examined in cases of sudden heart death in 50 persons of both sexes whose ages ranged from 25 to 55. The microscopic and biochemical findings were compared with those in cases of heart death which had not occurred suddenly in patients with myocardial infarction of different duration (50 cases). It is shown that in sudden heart death diffuse edema of the white matter and dystonic changes in the microcirculation vessels develop in the hypothalamus. Biochemical examination discloses in the tissue of the hypothalamus in such cases a sharp decrease in the content of noradrenalin and the precursor of catecholamine synthesis DOPA and a marked increase in the level of adrenalin. It is assumed that there is a causative connection between vascular dystonia and the decrease in the noradrenalin level. An increase in the adrenalin content may be conducive to the intensification of cerebral hydrophilism.
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PMID:[Hypothalamic characteristics in sudden human cardiac death]. 740 43

The article reviews the recent scientific literature and the authors' studies on this topic. Occupational conditions and psychological factors have been shown to play an important role in the etiopathogenesis of cardiovascular diseases. Their effect is often indirect, through damage to the central nervous, respiratory, and neuroendocrine systems. Hot climate in the workplace and intense infrared radiation cause the water and electrolyte imbalance and chronic hyperthermia and manifests as neurovegetative dystonia. The long-term effects of low temperatures condition ischemic lesions in circulatory system, trophic organ destruction. The influence of ultrahigh-frequency electromagnetic radiation on the cardiovascular system is directly related to the central nervous system and neurohumoral lesions. "Microwave disease" often manifests as polymorphic dystonia. Exposure to occupational vibration causes "white finger" syndrome or Raynaud's phenomenon together with cerebral vascular lesions. Recent studies have confirmed that noise as a chronic stressor causes the imbalance in the central and vegetative nervous systems and changes in homeostasis. Noise increases catecholamine and cholesterol concentration in blood, has an effect on plasma lipoprotein levels, increases heart rate, arterial blood pressure, and risk of myocardial infarction. Psychophysiological changes caused by long-term stress influence constant pathological changes in the central nervous system, endocrine and cardiovascular systems. The long-term effect of psychogenic stressors is very important in the etiopathogenesis of psychosomatic diseases.
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PMID:[The influence of occupational environment and professional factors on the risk of cardiovascular disease]. 1732 43


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