Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mumps virus is one of the most common causes of viral meningitis. Although brain involvement has been observed in a low proportion of children with mumps meningitis, a pure form of mumps encephalitis is extremely uncommon in the adult. A 23 year-old man presented with a rapidly evolving syndrome of cephalalgia , vomiting, mutism, disorders of gait, somnolence and dystonic movements. The electroencephalogram showed a diffusely slowed background activity. The CSF contained no cells, but the total protein concentration was elevated. The patient recovered without sequelae, but severe intellectual and motor disturbances persisted during more than a month. Serological studies showed an increase of blood IgM mumps-specific antibodies. We conclude that mumps encephalitis, although infrequent, should be considered among viral diseases that mimic herpes simplex encephalitis in the adulthood.
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PMID:[Mumps encephalitis in adulthood]. 205

To study the frequency and type of movement disorders and correlate these with MRI findings and outcome. Consecutive patients having encephalitis with movement disorders were included. The encephalitides were categorized into Japanese encephalitis (JE), herpes simplex, dengue, mumps, measles and nonspecific, depending on respective ELISA or CSF PCR. The movement disorders were recorded and severity was graded into mild, moderate, severe and markedly severe. Cranial MRI was done on a 1.5 T scanner acquiring T1, T2 and FLAIR sequence, and the location of MRI changes was noted. Outcome was defined at 6 months on the basis of functional status into complete, partial or poor. The type and severity of movement disorders and their relation to outcome was evaluated. Seventy-four out of 209 encephalitis patients had movement disorders; 67.6% of the patients had JE, 51.2% nonspecific and 11.3% dengue encephalitis. Their median age was 19 years and 16 were females. Parkinsonian features were present in 36, dystonia in six and both in 32 patients. The severity of movement disorders ranged between 2 and 4 (scale: none = 0, mild = 1, moderate = 2, severe = 3, markedly severe = 4). Movement disorders were common in males (P = 0.0001), and more frequent in JE (P = 0.03) and those having substantia nigra involvement on MRI (P = 0.03). Dystonia was associated with worse outcome than parkinsonian features only (P = 0.01). Movement disorders are common and severe in JE and are related to typical anatomical involvement.
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PMID:Spectrum of movement disorders in encephalitis. 2064 May 77